A while back, we were discussing the (in)desirability of eliminating fear.

Nature has an article on a related subject, "An SCN9A channelopathy causes congenital inability to experience pain":

The index case for the present study was a ten-year-old child, well known to the medical service after regularly performing 'street theatre'. He placed knives through his arms and walked on burning coals, but experienced no pain. He died before being seen on his fourteenth birthday, after jumping off a house roof.

It would appear that lack of normal risk-aversion can be somewhat unhealthy.

Subsequently, we studied three further consanguineous families in which there were individuals with similar histories of a lack of pain appreciation.

Judging by the family trees given in their Figure 1, "consanguineous" is the formal way of saying that one's family tree resembles an italian cypress.

None knew what pain felt like, although the older individuals realized what actions should elicit pain (including acting as if in pain after football tackles). All had injuries to their lips and/or tongue (with loss of the distal third in two cases), caused by biting themselves in the first 4 yr of life.

They follow this point with a laundry list of other injuries (undetected fractures, etc.) which, in their conclusion, leads to the following observation:

... affected individuals often suffer permanent injury during childhood because they fail to notice illnesses or injuries, and fail to learn pain-avoiding (severe risk-avoiding) behaviours -- as in this study's index case.

-Dave


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