Marshall, I don't know if they body breaks down cyclosporine, or if it is eliminated by the kidneys or liver. If eliminated by the kidneys, perhaps more water needs to be drunk.
Cyclosporine is metabolized by the kidney.....and the dose is very highly regulated. Usually when they get the dose stabalized, it stays that way indefinately.....that is why it is unusual for there to be such a significant change. As far as increasing her water consumption.........that, too, is very highly regulated. She ingests 1800cc's (60 oz) of fluid per day. That is also exactly the same everyday, so that wouldn't cause the discrepency in her cyclo levels. Thank you very much for your input. Please keep any further information heading my way. Christiane ----- Original Message ----- From: Marshall Dudley To: [email protected] Sent: Wednesday, December 13, 2000 7:43 AM Subject: Re: CS>I need your help................ First let me point out I am not a doctor. All I can say is that in the years of research I have done on CS I have never found one case of a drug interaction. Of course that does not mean there cannot be, just that it seems unlikely. I don't know if they body breaks down cyclosporine, or if it is eliminated by the kidneys or liver. If eliminated by the kidneys, perhaps more water needs to be drunk. Wish I could be of more help. Marshall Christiane Osowiecki wrote: Hello,I was referred to you by James from Allison's Apothecary. I have a question about a possible drug reaction with colloidal silver. Here are the details, so you can best answer my question. I make my own Colloidal Silver (without NaCl) to a concentration of 5 PPM. I have been giving a tsp. to my 4 1/2 year old daughter twice per day for the treatment of bronchitis and a sinus infection. Here's the catch................she is a kidney transplant. She is taking the antirejection drug Neoral (cyclosporine) and I was wondering if anyone knew if colloidal silver affects the cyclosporine levels in the body and blood. The reason that I question it is that her cyclosporine levels were high yesterday, and her dose has not been changed. I do know that some antibiotics cause the body to produce cyclosporine, so when she takes those, her cyclo dose must be reduced. Being that colloidal silver is a natural antibiotic, I thought that there may be a chance that it can have the same affect. Her sinus infection has cleared up and her nose is running clear.......she still has a terrible cough, but all that is clear also. I suspect that with such a low dose of colloidal silver, that we should be pretty safe as far as drug interactions go, but in light of how she has been reacting, I need to make sure. She has been crying and restless,very itchy, and not able to sleep...........all of her other lab results were very good, and there don't seem to be any other particular causes (i.e. headache, earache,etc.)so I am turning to you, in hopes of some answers. If you know anything about this, or if you need further clarification, please email me at [email protected] Thank you so much for your help!! Christiane
