Try downloading the latest drivers from here : 
https://www.canon.co.uk/support/consumer_products/products/fax__multifunctionals/inkjet/pixma_ts_series/pixma-ts5050.html?type=drivers&language=en&os=macos%2011.0%20(big%20sur)
 
<https://www.canon.co.uk/support/consumer_products/products/fax__multifunctionals/inkjet/pixma_ts_series/pixma-ts5050.html?type=drivers&language=en&os=macos%2011.0%20(big%20sur)>

Install both the scanning & printer drivers then optionally restart and see if 
it works again.
_      
Regards
Sam Mullen

+44 (0)7747778022 <tel://+447747778022>
[email protected] <mailto:[email protected]>
www.macambulance.com <http://www.macambulance.com/>

MacAmbulance Ltd.
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> On 8 Mar 2021, at 15:16, Virginia Routh <[email protected]> wrote:
> 
> My Canon TS5050 which has behaved beautifully over the past 3 years has 
> decided not to scan.  I get error message :
> 
> Scanner reported an error
> A required file is missing or corrupted, 
> or settings are incorrect.  
> Try the installation again.
> 
> Can Smuggers advise me how to do this?  I have looked at IJ Scan utility but 
> am none the wiser.  How do I install the scanner again?
> Virginia
> 
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