Hi,

Have you found a way to get the outfiles? I am trying to use the
prot.XML output on TPP but in doesn t work. I also tried to run
Sequest the command line, but it is not accepting the enzyme_number
for trypsin. It is complaing about the enzyme description lines

*** Unknown sequest.params entry: 0.      No_Enzyme
0       -               -
*** Unknown sequest.params entry: 1.      Trypsin
1       KR              P
*** Unknown sequest.params entry: 2.      Trypsin(KRLNH)
1       KRLNH           -

Thanks,

Daniel

On Sep 23, 4:44 pm, Nikhil Garge <[email protected]> wrote:
> Hello,
>
> Anybody has experience using "Proteome Discoverer 1.0" software for SEQUEST
> search. I use the Bioworks for SEQUEST search and new to "Proteome
> Discoverer 1.0".  few of my concerns are as follows:
>
> a) How to perform SEQUEST BATCH search using "Proteome Discoverer 1.0"? It
> seems to accept only ine raw file at a time. Do you know how can one supply
> multiple raw files for SEQEUST search?
> b) The output is *.msf file which can be exported into protXML file format.
> So does this mean "Proteome Discoverer 1.0" uses Protein Prophet algorithm
> to identify significant proteins?
> c) The SEQUEST search done through "Proteome Discoverer 1.0" doesnt seem to
> output *.out files (or pepXML files). I am more interested in individual
> peptide hits but dont see how one can get 1st and 2nd hit as we see in *.out
> file using Bioworks).
>
> I would really appreciate your feedback on this.
>
> Thanks,
> ~Nikhil.

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