No but it might help in debugging. You say TPP can't see the database
file in '/dbase/IPI/' which could mean that you store all your fasta
files in a directory called /dbase on a linux system. Alternatively,
this could be on a Windows system running cygwin. I couldn't tell
based on the error message.
I think Sequest file paths on Windows should look like this: C:\dbase
\IPI\ipi.MOUSE.v3.64_DECOY.fasta
NOT like what you posted: '/dbase/IPI/ipi.MOUSE.v3.64_DECOY.fasta'

Get the full path to your fasta file using Windows Explorer and use
that path in Sequest.

HTH,
GATTACA


On Dec 22, 3:42 am, hcadrexler <[email protected]> wrote:
> I am running Windows XP 32-bit - would it make a difference?
>
> On 21 Dez., 16:53, GATTACA <[email protected]> wrote:
>
> > What OS are you running? Windows? Linux?
>
> > On Dec 21, 3:54 am, hcadrexler <[email protected]> wrote:
>
> > > Hi everybody,
>
> > > currently I am trying to work my way through TPP. Subsequent to
> > > converting my Thermo .raw files to mzXML I tried to do a Sequest
> > > search with these files, using a decoy database that I generated with
> > > the TPP tool Decoy Database. Conversion seemed to work properly,
> > > however, when I start the search I immediately get the error message
> > > "Cannot read the database file '/dbase/IPI/
> > > ipi.MOUSE.v3.64_DECOY.fasta'.  Check that this filename is correct.".
> > > The file name appears to be correct, the file is located where it is
> > > supposed to be, the database is specified in the params file, yet....
> > > Does anybody have a clue on what might have gone wrong?

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