When I run from Discoverer, it asked me to select all the options and
generated a template which can be used later. As I search the
computer, no sequest.params files exists. But if I run sequest.exe
from
command line, it asks for sequest.params file.

I tried the params file you attached, it seems that the format is not
compatible :(

Thanks again!

On Mar 4, 4:08 pm, Jimmy Eng <[email protected]> wrote:
> You should search your Proteome Discoverer box for a file named
> 'sequest.params' as I don't have access to the Thermo version.  In
> fact, I wouldn't even know if sequest.params still exists under
> Discoverer.
>
> Here's the current params file we use at the UW (which is similar to
> but not directly the same as Thermo's version of this file).  Example
> modifications include a +16 variable mod on methionine and a static
> mod of +57 on cysteines:
>    http://proteomicsresource.washington.edu/sequest_params.php
>
> What we really need is someone to contribute a .msf to pep.xml converter!
>
>
>
> On Thu, Mar 4, 2010 at 3:49 PM, Ping <[email protected]> wrote:
> > Thanks Jimmy!
>
> > Is there any sequest.params sample with modifications I can get?
>
> > Thanks again!
>
> > Ping
>
> > On Mar 3, 5:16 pm, Jimmy Eng <[email protected]> wrote:
> >> unless there's a way to convert .msf to pep.xml, and I'm not aware of
> >> any tool that does this, you'll have to go the .out route.
>
> >> On Mar 3, 2:18 pm, Ping <[email protected]> wrote:
>
> >> > Hi All,
>
> >> > The output of the Proteome Discover is *.msf. Is there an easy way to
> >> > compute peptide prophet from it? Or I have to run sequest.exe to get
> >> > *.out to do so?
>
> >> > Thanks!
>
> >> > Ping
>
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