Jimmy,
thanks. So just to clarify, the process should be:
-take an existing sequence database
-create duplicate entries with reverse or randomized Amino Acid
sequences. Modify the Accession identifiers with <TAG>Identifier
-specify <TAG> when calling xinteract with the -d<tag> option

With Mascot, we have to be format the reverse/random entries to have
the same FASTA header line format, so that Mascot Regex's can parse
them along with the original entries..

regards
Simon


On Jun 30, 12:37 pm, Jimmy Eng <[email protected]> wrote:
> You can use any prefix as long as it's consistent (and obviously
> unique and not present in the target database entries).  In the tools,
> you will specify what prefix denotes the decoy entries.  Like "REV" or
> "### "or "###REV###" ...
>
> On Tue, Jun 29, 2010 at 7:23 PM, Simon Michnowicz
>
>
>
> <[email protected]> wrote:
> > Dear Group,
> > I am trying to create a decoy database for use in the TPP pipeline.
> > I downloaded a Perl  Script from Matrix Science, and noticed it put
> > entries like :
> > ###REV###
> > ###RND###
> > in Accession identifiers. However whilst looking at ISB slides noticed
> > that the Accession identifiers
> > are mentioned to be of the form “REV0” or “REV1”.‘REV’
>
> > Is placing  "REV' at the start of the protein name  the standard way
> > of formatting Accession identifiers for use with the ISB tools (i.e.
> > protein prophet)?
>
> > thanks
> > Simon Michnowicz
>
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