Hi,

I'm trying to get TPP to work with Myrimatch pepXML output. Everything
seems to be going okay but I get an error at the RefreshParser stage
(see output below). The only slightly unusual thing I did was to
change '.pepXML' extensions that Myrimatch produces to the TPP
convention '.pep.xml'. I'm using the windows release version (4.3.1)
on Windows Vista Business 64 bit (this configuration normally works
fine with TPP).

Many thanks for any suggestions,
Ben


# Commands for session DUQCFMUJJ on Wed Aug 11 13:41:25 2010
# BEGIN COMMAND BLOCK
###### BEGIN Command Execution ######
[Wed Aug 11 13:41:25 2010] EXECUTING: run_in c:/Inetpub/wwwroot/ISB/
data/ben_data/100721_MCF7_SCX; c:\Inetpub\tpp-bin\xinteract  -
Nmyri_test_interact.pep.xml -p0.05 -l7 -OA -ddecoy_ c:/Inetpub/wwwroot/
ISB/data/ben_data/100721_MCF7_SCX/100721_MCF7_SCX-r002.myri.pep.xml c:/
Inetpub/wwwroot/ISB/data/ben_data/100721_MCF7_SCX/100721_MCF7_SCX-
r003.myri.pep.xml c:/Inetpub/wwwroot/ISB/data/ben_data/100721_MCF7_SCX/
100721_MCF7_SCX-r004.myri.pep.xml
OUTPUT:

c:\Inetpub\tpp-bin\xinteract (TPP v4.3 JETSTREAM rev 1, Build
200909091257 (MinGW))

running: "C:/Inetpub/tpp-bin/InteractParser
"myri_test_interact.pep.xml" "c:/Inetpub/wwwroot/ISB/data/ben_data/
100721_MCF7_SCX/100721_MCF7_SCX-r002.myri.pep.xml" "c:/Inetpub/wwwroot/
ISB/data/ben_data/100721_MCF7_SCX/100721_MCF7_SCX-r003.myri.pep.xml"
"c:/Inetpub/wwwroot/ISB/data/ben_data/100721_MCF7_SCX/100721_MCF7_SCX-
r004.myri.pep.xml" -L"7""
 file 1: c:/Inetpub/wwwroot/ISB/data/ben_data/100721_MCF7_SCX/
100721_MCF7_SCX-r002.myri.pep.xml
 file 2: c:/Inetpub/wwwroot/ISB/data/ben_data/100721_MCF7_SCX/
100721_MCF7_SCX-r003.myri.pep.xml
 file 3: c:/Inetpub/wwwroot/ISB/data/ben_data/100721_MCF7_SCX/
100721_MCF7_SCX-r004.myri.pep.xml
 processed altogether 41870 results


 results written to file c:/Inetpub/wwwroot/ISB/data/ben_data/
100721_MCF7_SCX/myri_test_interact.pep.xml

 direct your browser to 
http://localhost/ISB/data/ben_data/100721_MCF7_SCX/myri_test_interact.pep.shtml



command completed in 231 sec

running: "C:/Inetpub/tpp-bin/PeptideProphetParser
"myri_test_interact.pep.xml" MINPROB=0.05 ACCMASS DECOY=decoy_"
using Accurate Mass Bins
Using Decoy Label "decoy_".
 (MyriMatch)
WARNING!! The discriminant function for Myrimatch is not yet
complete.  It is presented here to help facilitate trial and
discussion.  Reliance on this code for publishable scientific results
is not recommended.
WARNING: Myrimatch only support semi-parametric PeptideProphet
modelling, which relies on a DECOY search.
adding Accurate Mass mixture distr
WARNING: Myrimatch only support semi-parametric PeptideProphet
modelling, which relies on a DECOY search.
WARNING: Myrimatch only support semi-parametric PeptideProphet
modelling, which relies on a DECOY search.
WARNING: Myrimatch only support semi-parametric PeptideProphet
modelling, which relies on a DECOY search.
WARNING: Myrimatch only support semi-parametric PeptideProphet
modelling, which relies on a DECOY search.
WARNING: Myrimatch only support semi-parametric PeptideProphet
modelling, which relies on a DECOY search.
WARNING: Myrimatch only support semi-parametric PeptideProphet
modelling, which relies on a DECOY search.
init with MyriMatch
MS Instrument info: Manufacturer: UNKNOWN, Model: UNKNOWN, Ionization:
UNKNOWN, Analyzer: UNKNOWN, Detector: UNKNOWN

 PeptideProphet  (TPP v4.3 JETSTREAM rev 1, Build 200909091257
(MinGW)) akel...@isb
 read in 399 1+, 19065 2+, 17201 3+, 758 4+, 56 5+, 5 6+, and 4 7+
spectra.
Initialising statistical models ...
Iterations: .........10.........20.........30
WARNING: Mixture model quality test failed for charge (1+).
WARNING: Mixture model quality test failed for charge (5+).
WARNING: Mixture model quality test failed for charge (6+).
WARNING: Mixture model quality test failed for charge (7+).
model complete after 31 iterations
command completed in 315 sec

running: "C:/Inetpub/tpp-bin/ProphetModels.pl -i
myri_test_interact.pep.xml"
Analyzing myri_test_interact.pep.xml ...
Reading Accurate Mass Model model +1 ...
Reading Accurate Mass Model model +2 ...
Reading Accurate Mass Model model +3 ...
Reading Accurate Mass Model model +4 ...
Reading Accurate Mass Model model +5 ...
Reading Accurate Mass Model model +6 ...
Reading Accurate Mass Model model +7 ...
Parsing search results "100721_MCF7_SCX-r002 (MyriMatch)"...
  => Total of 313 hits.
Parsing search results "100721_MCF7_SCX-r003 (MyriMatch)"...
  => Total of 4614 hits.
Parsing search results "100721_MCF7_SCX-r004 (MyriMatch)"...
  => Total of 4303 hits.
command completed in 11 sec

running: "C:/Inetpub/tpp-bin/DatabaseParser
"myri_test_interact.pep.xml""
command completed in 3 sec

running: "C:/Inetpub/tpp-bin/RefreshParser
"myri_test_interact.pep.xml" "C:\Inetpub\wwwroot\ISB\data\dbase
\uniprot_human_CP_canonical_isoform_cRAP_decoy_2010_08.fasta""

command "C:/Inetpub/tpp-bin/RefreshParser "myri_test_interact.pep.xml"
"C:\Inetpub\wwwroot\ISB\data\dbase
\uniprot_human_CP_canonical_isoform_cRAP_decoy_2010_08.fasta"" failed:
Unknown error

command "C:/Inetpub/tpp-bin/RefreshParser "myri_test_interact.pep.xml"
"C:\Inetpub\wwwroot\ISB\data\dbase
\uniprot_human_CP_canonical_isoform_cRAP_decoy_2010_08.fasta"" exited
with non-zero exit code: 255
QUIT - the job is incomplete

command "c:\Inetpub\tpp-bin\xinteract -Nmyri_test_interact.pep.xml -
p0.05 -l7 -OA -ddecoy_ c:/Inetpub/wwwroot/ISB/data/ben_data/
100721_MCF7_SCX/100721_MCF7_SCX-r002.myri.pep.xml c:/Inetpub/wwwroot/
ISB/data/ben_data/100721_MCF7_SCX/100721_MCF7_SCX-r003.myri.pep.xml c:/
Inetpub/wwwroot/ISB/data/ben_data/100721_MCF7_SCX/100721_MCF7_SCX-
r004.myri.pep.xml" failed: Unknown error
END OUTPUT
RETURN CODE:65280
###### End Command Execution ######
# All finished at Wed Aug 11 13:51:14 2010
# END COMMAND BLOCK

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