Hi,
We recently upgraded an old version of TPP (Squall v3.3) to v4.3 rev1.
We've noticed an increase in the number of high confidence  (<1% FDR)
peptides and proteins. Digging into the pepXml files we've seen cases
where, for example, a peptide previously assigned a probability of < .
5 now scores > .9. Note that the Mascot scores haven't changed

Where can I learn about the differences between versions of the
Prophets?
Thanks
John

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