Hi Julia,
Try this post for .msf converter.
Proteome Discoverer's .msf to TPP input files (pepXML)
http://groups.google.com/group/spctools-discuss/browse_thread/thread/bbfad1a9a04d775f/9497da1edc9fd2d0?lnk=gst&q=Proteome+Discoverer%27s+.msf+to+TPP+input+files+(pepXML)#9497da1edc9fd2d0.

I have had similar issues since going to PD from Bioworks.
Try to change path in sys. var. to C:\Program Files\Thermo\Discoverer
\System\Release.  I do not think copying the .exe will work.



On Dec 28, 2:16 pm, "[email protected]"
<[email protected]> wrote:
>  I want to use Sequest from TPP, thus I am using TPP in the same
> computer where I have installed Proteome Discover (PD) 1.0 (with
> Sequest). First, the output of sequest from PD is not *.out that is
> necessary for conversion to pepxml. Does anyone know a way to convert
> this file into pepxml? As I was unable to obtain this conversion, I
> tryed to use Database search with SEQUEST in TPP. I got many errors,
> such as " couldnt find sequest.exe at  c;/xcalibur\systems\programs
> \bioworksbrowser, although sequest is perfectely running at PD. Thus,
> I created a folder at the above destination and copied the
> sequest.exe. I also, created a sequest.params using a model 
> athttp://proteomicsresource.washington.edu/sequest_release/release_2011....
> (I just changed thedatabase destination folder ). Thus, I ran my mzxml
> file and I got no results. Here is the message. I really appreciate if
> someone could help me!
> Best regards! And A happy new year!
>
> julia
>
> ------------
>
> 2650  099%
>    2651  100%
>
>  Done.
>
> chmod g+w IT_20110824_06; cp c:/Inetpub/wwwroot/ISB/data/parameters/
> sequest.params IT_20110824_06
> cd IT_20110824_06; find . -maxdepth 1 -depth -name
> "IT_20110824_06*.dta" -print | xargs --max-args=50 c:/xcalibur/system/
> programs/bioworksbrowser/sequest.exe -Pc:/Inetpub/wwwroot/ISB/data/
> parameters/sequest.params
>
> command "c:\Inetpub\wwwroot\..\tpp-bin\find.exe . -maxdepth 1 -depth -
> name "IT_20110824_06*.dta" -print | xargs --max-args=50 c:/xcalibur/
> system/programs/bioworksbrowser/sequest.exe -Pc:/Inetpub/wwwroot/ISB/
> data/parameters/sequest.params" failed: Unknown error
> command "cd IT_20110824_06; find . -maxdepth 1 -depth -name
> "IT_20110824_06*.dta" -print | xargs --max-args=50 c:/xcalibur/system/
> programs/bioworksbrowser/sequest.exe -Pc:/Inetpub/wwwroot/ISB/data/
> parameters/sequest.params" failed with exit code 123
> Out2XML IT_20110824_06 1
> params file here: IT_20110824_06/sequest.params
>
> Command Successful

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