Hi All,

I am analyzing the SWATH-MS data using the DIA-Umpire. And I have 3 data 
files of same sample which lead to generation of 9 .mgf output files from 
DIA-Umpire, which were converted into 9 mzXML and then subjected to Comet 
and X! Tandem search, and subsequently to peptide prophet and hence total 
files generated during this process are 18 pep.xml files. 
My ultimate aim to build the assay library. So, I am confused how to 
combine the results of these 18 peptideprophet files.

Should I combine the Comet search results of each data file separately and 
X! Tandem results separately and then combine these outputs again using 
iProphet? This should result in generation of 3 iprophet result files 
corresponding to each data file, which can again combined into one file by 
iProphet in final step?

Or there is another way out of this problem?
   
Thanks

Ankit

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