Hello Emily,

This is not a problem that we have seen much of.  Do you know which version
of ProteinProphet / TPP you are using?

One potential issue is the large number of proteins (and peptides) that it
is trying to process -- can you either monitor the memory usage of the
machine when you run this dataset, and/or try on one with more memory?

Hope this helps,
--Luis


On Tue, Oct 6, 2020 at 6:32 PM Emily Kawaler <[email protected]> wrote:

> Hello! I've been running ProteinProphet as part of the Philosopher
> pipeline for a while now with no problems. However, one of my datasets
> seems to be getting stuck in the middle of this function. It doesn't throw
> an error or anything - just stops advancing (the last
> line of the output is "Computing degenerate peptides for 69919 proteins:
> 0%...10%...20%...30%...40%...50%"). Has anyone run into this problem before?
>
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