Hello Emily,

If you are able to share the dataset including the pepXML file and the
database I can try to replicate the issue here and try to troubleshoot the
sticking point.

Thanks,
-David

On Tue, Oct 13, 2020 at 11:15 AM Emily Kawaler <[email protected]> wrote:

> Hello, and thank you for your response! It doesn't look like the process
> is using too much memory (I've allocated 300 GB and it's maxing out around
> 10), and I've kicked up the minprob parameter - it's still getting stuck,
> unfortunately.
> Emily
>
> On Friday, October 9, 2020 at 2:24:37 PM UTC-4 Luis wrote:
>
>> Hello Emily,
>>
>> This is not a problem that we have seen much of.  Do you know which
>> version of ProteinProphet / TPP you are using?
>>
>> One potential issue is the large number of proteins (and peptides) that
>> it is trying to process -- can you either monitor the memory usage of the
>> machine when you run this dataset, and/or try on one with more memory?
>>
>> Hope this helps,
>> --Luis
>>
>>
>> On Tue, Oct 6, 2020 at 6:32 PM Emily Kawaler <[email protected]> wrote:
>>
>>> Hello! I've been running ProteinProphet as part of the Philosopher
>>> pipeline for a while now with no problems. However, one of my datasets
>>> seems to be getting stuck in the middle of this function. It doesn't throw
>>> an error or anything - just stops advancing (the last
>>> line of the output is "Computing degenerate peptides for 69919 proteins:
>>> 0%...10%...20%...30%...40%...50%"). Has anyone run into this problem before?
>>>
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