Hi Sud,
Here is a Comet parameters file with the TMT tags set as static 
modifications (see bottom of the file):
https://github.com/pwilmart/Metaplastic-BC_PXD014414/blob/master/comet.params
The tags are +229.1629 Da on the peptide N-term and on lysine residues. I 
have an open source pipeline that uses Comet and supports TMT labeling:
https://github.com/pwilmart/PAW_pipeline
There are also many other resources at my GitHub site for TMT analyses.
Cheers,
Phil

On Sunday, December 20, 2020 at 9:30:16 PM UTC-8 [email protected] wrote:

> Can anyone please hare with me The *"comet search parameters for TMT 
> 6plex labeled tryptic peptides*???
> It will be a great help.
> Regards,
> Sud
>

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