Hi Jen, Here are some ideas about using some of the commands in the installed version of UMLS::Similarity to find nearby branches of a given term of CUI. A lot more information about the different commands available can be found at :
http://search.cpan.org/dist/UMLS-Interface/ http://search.cpan.org/dist/UMLS-Interface/ I'm not certain how useful this all will be, but wanted to let you know what I was thinking at least. Please feel free to follow up as needed. tpederse@maraca:~$ getAssociatedCuis.pl "Diabetes Mellitus" UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The CUIs associated with Diabetes Mellitus are: 1. C0011849 tpederse@maraca:~$ getChildren.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The children of Diabetes mellitus NOS (C0011849) are: leprechaunism (C0265344) experimental diabetes mellitus (C0011853) compl diabetes mellitus (C0342257) diabetes mellitus, sudden-onset (C0011854) pregnancy-induced diabetes (C0085207) states, prediabetic (C0362046) noninsulin-dependent diabetes mellitus (C0011860) acidoses, diabetic (C0011880) tpederse@maraca:~$ getParents.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The parents of Diabetes mellitus NOS (C0011849) are: endocrine system diseases(C0014130) metabolism disorder, glucose(C1257958) tpederse@maraca:~$ getAssociatedCuis.pl No term was specified on the command line Usage: getAssociatedCuis.pl [OPTIONS] TERM Type getAssociatedCuis.pl --help for help. tpederse@maraca:~$ getAssociatedCuis.pl "Diabetes Mellitus" UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The CUIs associated with Diabetes Mellitus are: 1. C0011849 tpederse@maraca:~$ getChildren.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The children of Diabetes mellitus NOS (C0011849) are: leprechaunism (C0265344) experimental diabetes mellitus (C0011853) compl diabetes mellitus (C0342257) diabetes mellitus, sudden-onset (C0011854) pregnancy-induced diabetes (C0085207) states, prediabetic (C0362046) noninsulin-dependent diabetes mellitus (C0011860) acidoses, diabetic (C0011880) tpederse@maraca:~$ getParents.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The parents of Diabetes mellitus NOS (C0011849) are: endocrine system diseases(C0014130) metabolism disorder, glucose(C1257958) tpederse@maraca:~$ getRelated.pl C0011849 RB UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL No CUIs are associated with diabetes mellitus (C0011849) given the relation (RB). tpederse@maraca:~$ getRelated.pl C0011849 RN UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The related (RN) CUIs to diabetes mellitus (C0011849): premature aging, okamoto type (C2930860) lipoatrophy with diabetes, hepatic steatosis, cardiomyopathy, and leukomelanodermic papules (C2931057) feigenbaum bergeron richardson syndrome (C2931125) thiamine responsive megaloblastic anemia syndrome (C0342287) yorifuji okuno syndrome (C2931296) extrapyramidal disorder, progressive, with primary hypogonadism, mental retardation, and alopecia (C0342286) pancreatic beta cell agenesis with neonatal diabetes mellitus (C1838655) photomyoclonus, diabetes mellitus, deafness, nephropathy, and cerebral dysfunction (C1809475) furukawa takagi nakao syndrome (C2931765) diabetes mellitus, neonatal, with congenital hypothyroidism (C1857775) diabetes mellitus, transient neonatal, 2 (C1835887) developmental delay, epilepsy, and neonatal diabetes (C1853564) mitochondrial myopathy with diabetes (C1839028) diabetes mellitus, transient neonatal, 3 (C1864623) diabetes mellitus, insulin-resistant, with acanthosis nigricans (C0342278) maturity-onset diabetes of the young, type 7 (C1864839) mitchell-riley syndrome (C2748662) hyperproinsulinemia (C0342283) muscular atrophy, ataxia, retinitis pigmentosa, and diabetes mellitus (C0342281) 6q24-related transient neonatal diabetes mellitus (C3711391) diabetes mellitus, congenital autoimmune (C1857958) pancreatic and cerebellar agenesis (C1836780) stimmler syndrome (C1859965) atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease (C1859596) diabetes insipidus and mellitus with optic atrophy and deafness, mitochondrial form (C1838782) diabetes mellitus, transient neonatal, 1 (C1832386) pancreatic hypoplasia, congenital, with diabetes mellitus and congenital heart disease (C1838780) lymphedema-distichiasis syndrome with renal disease and diabetes mellitus (C2675066) diabetes mellitus, permanent neonatal, with neurologic features (C1833102) diabetes mellitus, permanent, of infancy (C1833104) martinez frias syndrome (C1832443) UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The CUIs associated with Diabetes Mellitus are: 1. C0011849 tpederse@maraca:~$ getChildren.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The children of Diabetes mellitus NOS (C0011849) are: leprechaunism (C0265344) experimental diabetes mellitus (C0011853) compl diabetes mellitus (C0342257) diabetes mellitus, sudden-onset (C0011854) pregnancy-induced diabetes (C0085207) states, prediabetic (C0362046) noninsulin-dependent diabetes mellitus (C0011860) acidoses, diabetic (C0011880) tpederse@maraca:~$ getParents.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The parents of Diabetes mellitus NOS (C0011849) are: endocrine system diseases(C0014130) metabolism disorder, glucose(C1257958) tpederse@maraca:~$ getAssociatedCuis.pl No term was specified on the command line Usage: getAssociatedCuis.pl [OPTIONS] TERM Type getAssociatedCuis.pl --help for help. tpederse@maraca:~$ getAssociatedCuis.pl "Diabetes Mellitus" UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The CUIs associated with Diabetes Mellitus are: 1. C0011849 tpederse@maraca:~$ getChildren.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The children of Diabetes mellitus NOS (C0011849) are: leprechaunism (C0265344) experimental diabetes mellitus (C0011853) compl diabetes mellitus (C0342257) diabetes mellitus, sudden-onset (C0011854) pregnancy-induced diabetes (C0085207) states, prediabetic (C0362046) noninsulin-dependent diabetes mellitus (C0011860) acidoses, diabetic (C0011880) tpederse@maraca:~$ getParents.pl C0011849 UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The parents of Diabetes mellitus NOS (C0011849) are: endocrine system diseases(C0014130) metabolism disorder, glucose(C1257958) tpederse@maraca:~$ getRelated.pl C0011849 RB UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL No CUIs are associated with diabetes mellitus (C0011849) given the relation (RB). tpederse@maraca:~$ getRelated.pl C0011849 RN UMLS-Interface Configuration Information: (Default Information - no config file) Sources (SAB): MSH Relations (REL): PAR CHD Sources (SABDEF): UMLS_ALL Relations (RELDEF): UMLS_ALL The related (RN) CUIs to diabetes mellitus (C0011849): premature aging, okamoto type (C2930860) lipoatrophy with diabetes, hepatic steatosis, cardiomyopathy, and leukomelanodermic papules (C2931057) feigenbaum bergeron richardson syndrome (C2931125) thiamine responsive megaloblastic anemia syndrome (C0342287) yorifuji okuno syndrome (C2931296) extrapyramidal disorder, progressive, with primary hypogonadism, mental retardation, and alopecia (C0342286) pancreatic beta cell agenesis with neonatal diabetes mellitus (C1838655) photomyoclonus, diabetes mellitus, deafness, nephropathy, and cerebral dysfunction (C1809475) furukawa takagi nakao syndrome (C2931765) diabetes mellitus, neonatal, with congenital hypothyroidism (C1857775) diabetes mellitus, transient neonatal, 2 (C1835887) developmental delay, epilepsy, and neonatal diabetes (C1853564) mitochondrial myopathy with diabetes (C1839028) diabetes mellitus, transient neonatal, 3 (C1864623) diabetes mellitus, insulin-resistant, with acanthosis nigricans (C0342278) maturity-onset diabetes of the young, type 7 (C1864839) mitchell-riley syndrome (C2748662) hyperproinsulinemia (C0342283) muscular atrophy, ataxia, retinitis pigmentosa, and diabetes mellitus (C0342281) 6q24-related transient neonatal diabetes mellitus (C3711391) diabetes mellitus, congenital autoimmune (C1857958) pancreatic and cerebellar agenesis (C1836780) stimmler syndrome (C1859965) atherosclerosis, premature, with deafness, nephropathy, diabetes mellitus, photomyoclonus, and degenerative neurologic disease (C1859596) diabetes insipidus and mellitus with optic atrophy and deafness, mitochondrial form (C1838782) diabetes mellitus, transient neonatal, 1 (C1832386) pancreatic hypoplasia, congenital, with diabetes mellitus and congenital heart disease (C1838780) lymphedema-distichiasis syndrome with renal disease and diabetes mellitus (C2675066) diabetes mellitus, permanent neonatal, with neurologic features (C1833102) diabetes mellitus, permanent, of infancy (C1833104) martinez frias syndrome (C1832443)
