For some of our clusters we use a slightly different approach with the F5s:

[1. F5] -> [2. Varnish pool] -> [3. F5] -> [4. Tomcat pool]

By going back through the F5, this setup allows us to keep all of our backend 
selection logic (not to mention other iRule goodness) together in the F5 
configs instead of VCL. We've been using this scheme for quite some time w/good 
results - the extra hop is negligible in terms of latency vs. the average 
backend response times for dynamic requests.

And we likewise don't have an issue w/redundant cache data for our use-cases. 
The extra backend request per Varnish instance per TTL period is minor vs. the 
impact of losing a Varnish instance that is the sole cache for a large 
percentage of your URL space. I think hashed based balancing is generally 
better for static content.

-bret

On Fri, Jan 28, 2011 at 03:55:47PM +0100, jdzstz - gmail dot com wrote:
> In my opinion, the problem of having separate caching based on URL is
> that in case of problems, secondary failover server has a empty cache
> for rest of URL, so can affect to throughtput.
> 
> Our architecture is the following:
> 
> [1. F5 LB] => [2. Varnish]  => [3. Tomcat]
> 
> 1) F5 Big IP Hardware Load Balancer
> 2) Four Varnish cache in diferent machines
> 3) Four Tomcat servers in diferent machines
> 
> We don't care to have redundant caching because:
>   -  we don't have resource problems
>   -  in case of problems, all varnish instances has the cache already 
> populated
> 


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