Hi Sikandar,

The procedure you are describing will not give you PMF. I don't even
know what exactly this is going to be.

An alternative approach would be to fix the positions of the centers
of mass of two water molecules at a distance r and measure a total
force (r) on each of them during the MD run. Integrating this force as
a function of r you will obtain PMF. This of course requires a special
MD run and is similar to the pull code, except you don't have to
subtract the rotational entropy at the end.

cheers,
Denis

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