Hey Denis

Thank you very much for clarifications.

--
sikandar

On Mon, Oct 11, 2010 at 1:23 PM, Denis Andrienko
<[email protected]>wrote:

> Hi Sikandar,
>
> The procedure you are describing will not give you PMF. I don't even
> know what exactly this is going to be.
>
> An alternative approach would be to fix the positions of the centers
> of mass of two water molecules at a distance r and measure a total
> force (r) on each of them during the MD run. Integrating this force as
> a function of r you will obtain PMF. This of course requires a special
> MD run and is similar to the pull code, except you don't have to
> subtract the rotational entropy at the end.
>
> cheers,
> Denis
>
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