Hello,

I managed to run the RE iteration for a system with 10 non-bonded 
potentials (types).. well, the first iteration anyway, where it terminated 
after about an hour of running csg_reupdate with the following error:

*Hessian NOT a positive definite! *
This can be a result of poor initial guess or ill-suited CG potential 
settings or poor CG sampling.

My understanding is, sometimes this might happen, but this was my second 
trial where I virtually doubled (44 -> 88) the number of knots and (in both 
cases) I use potentials derived from an earlier IBI iteration. 

I would really appreciate clues, hints or general advice as to how to 
alleviate the issue.

Thanks!
Andrey

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