On Thu, Jul 19, 2018 at 18:15 'Andrey Brukhno' via votca <
[email protected]> wrote:

> Hello,
>
> I managed to run the RE iteration for a system with 10 non-bonded
> potentials (types).. well, the first iteration anyway, where it terminated
> after about an hour of running csg_reupdate with the following error:
>
> *Hessian NOT a positive definite! *
> This can be a result of poor initial guess or ill-suited CG potential
> settings or poor CG sampling.
>
> My understanding is, sometimes this might happen, but this was my second
> trial where I virtually doubled (44 -> 88) the number of knots and (in both
> cases) I use potentials derived from an earlier IBI iteration.
>
> I would really appreciate clues, hints or general advice as to how to
> alleviate the issue.
>
Sikandar will know more, but most likely you will need to throw away some
frames at the beginning of the trajectory and run the iterations for a bit
longer!

Christoph

>
> Thanks!
> Andrey
>
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-- 
Christoph Junghans
Web: http://www.compphys.de

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