Wow, that’s pretty impressive. I hadn’t realized the high levels of DQE you had achieved. If you could make one for visible photons, you’d make a lot of microscopists really happy.
I also had not realized that QE of other detectors is intensity dependent—seems counter-intuitive. JPK +++++++++++++++++++++++++++++++++++++++++++++++++ Jacob Pearson Keller Research Scientist / Looger Lab HHMI Janelia Research Campus 19700 Helix Dr, Ashburn, VA 20147 Desk: (571)209-4000 x3159 Cell: (301)592-7004 +++++++++++++++++++++++++++++++++++++++++++++++++ The content of this email is confidential and intended for the recipient specified in message only. It is strictly forbidden to share any part of this message with any third party, without a written consent of the sender. If you received this message by mistake, please reply to this message and follow with its deletion, so that we can ensure such a mistake does not occur in the future. From: Marcus Winter <marcus.win...@rigaku.com> Sent: Wednesday, January 16, 2019 11:25 AM To: Keller, Jacob <kell...@janelia.hhmi.org>; CCP4BB@JISCMAIL.AC.UK Subject: [ccp4bb] hybrid photon counter in the home lab Dear Jacob, Thank you for your reply. You’re correct, of course. As shown below and in the attachment, with Si sensors and at a photon energy of the 8 keV, the DQE of both the HyPix-6000HE and Pilatus3 R 200K HPC detectors are both considerably above 90%. [cid:image001.png@01D4AD9E.60DA3C20] Most importantly, this high DQE is maintained throughout the operating regime: from the highest to the lowest count rates. As can be seen, this is in contrast to the highest performing CCD detector (the Atlas S2) and CMOS type detectors. The high DQE even at the lowest count rates / lowest reflection intensities is the reason for the best quality highest resolution data to be collectable using the HPC technology detectors. Many Thanks, Yours sincerely, Marcus Winter Rigaku. From: Keller, Jacob [mailto:kell...@janelia.hhmi.org] Sent: Wednesday, January 16, 2019 2:13 PM To: Marcus Winter <marcus.win...@rigaku.com<mailto:marcus.win...@rigaku.com>>; CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK> Subject: RE: [ccp4bb] hybrid photon counter in the home lab Doesn’t the phrase “each-and-every single photon counting capability” imply that quantum efficiency is 100%? I don’t think this is possible—what is the quantum efficiency of these detectors? JPK +++++++++++++++++++++++++++++++++++++++++++++++++ Jacob Pearson Keller Research Scientist / Looger Lab HHMI Janelia Research Campus 19700 Helix Dr, Ashburn, VA 20147 Desk: (571)209-4000 x3159 Cell: (301)592-7004 +++++++++++++++++++++++++++++++++++++++++++++++++ The content of this email is confidential and intended for the recipient specified in message only. It is strictly forbidden to share any part of this message with any third party, without a written consent of the sender. If you received this message by mistake, please reply to this message and follow with its deletion, so that we can ensure such a mistake does not occur in the future. From: CCP4 bulletin board <CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK>> On Behalf Of Marcus Winter Sent: Wednesday, January 16, 2019 3:28 AM To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK> Subject: [ccp4bb] hybrid photon counter in the home lab Dear Wolfram, For the past several years, Rigaku has been installing only HPC (Hybrid Photon Counting) X-ray area detector -based diffractometer systems: in conjunction with microfocus rotating anode, microfocus sealed-tube and other X-ray sources. (Most recently, we have been deploying the Rigaku HyPix-6000HE HPC detector.) The advantages of the HPC technology over any of the phosphor-based detector types (CCD, CMOS and CPAD, etc…) are notable: most particularly the discrete each-and-every single photon counting capability, extremely high dynamic range, small pixel size and the single pixel point function and very rapid read-out. With these advantages, significantly higher resolution data can be achieved, - and more speedily, compared to the other detector types. (We have a number of established ‘application note’ examples.) In order to prove the advantages for your purposes, the best might be to collect data from a range of your own crystal samples. – There is an open invitation for any seriously interested groups to collect data from their crystals in our applications labs. Please contact your local good Rigaku salesperson. Many Thanks, Yours sincerely, Marcus Winter Rigaku. From: CCP4 bulletin board [mailto:CCP4BB@JISCMAIL.AC.UK] On Behalf Of wtempel Sent: Tuesday, January 15, 2019 6:20 PM To: CCP4BB@JISCMAIL.AC.UK<mailto:CCP4BB@JISCMAIL.AC.UK> Subject: [ccp4bb] hybrid photon counter in the home lab Hi, I would value your opinions in this equipment-related question. Allé et al have compared detector types with a molybdemon source for a small molecule application<https://dx.doi.org/10.1088/0031-8949/91/6/063001>. Are there similar published comparisons for protein crystallography? What benefits can I expect from replacing a CCD detector with a hybrid photon counter at an energy of 8 keV and in the absence of the flux that a modern synchrotron provides? Thank you in advance. Wolfram Tempel ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 ________________________________ To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
