Hi Michael,

I’m happy to hear you are making good progress with CIFTI and Connectome 
Workbench.  You can indeed use the PALM software to do statistical inference on 
CIFTI data, and that is the tool we recommend.
Peace,

Matt.

From: 
<hcp-users-boun...@humanconnectome.org<mailto:hcp-users-boun...@humanconnectome.org>>
 on behalf of "Regner, Michael" 
<michael.reg...@ucdenver.edu<mailto:michael.reg...@ucdenver.edu>>
Date: Monday, July 10, 2017 at 2:40 AM
To: "hcp-users@humanconnectome.org<mailto:hcp-users@humanconnectome.org>" 
<hcp-users@humanconnectome.org<mailto:hcp-users@humanconnectome.org>>
Subject: [HCP-Users] Statistical comparison of whole brain (surface "voxels" + 
subcortical / cerebellar voxels) connectivity between two explicitly defined 
voxels

Dear HCP Community,

I am relatively new to the HCP data and Connectome Workbench.  Our 
neuroradiology laboratory at the University of Colorado is beginning to use it. 
 It has already proved to be extremely helpful in aiding the interpretation of 
existing resting state results.

My question is:  does the HCP Connectome Workbench provide an internal 
mechanism for the generation of statistical comparisons / contrasts within or 
between CIFTI files?  I am exploring the dense resting state connectivity data. 
 My goal is to construct a contrast map for statistical inference.  I would 
like to compare whole brain (surface "voxels" + subcortical / cerebellar 
voxels) connectivity between two explicitly defined voxels within the dense 
resting state connectivity CIFTI file (or construct new whole-brain 
connectivity map CIFTI files for two explicitly defined voxels, and 
statistically compare these two maps).  So, the desired resultant map / CIFTI 
file would illustrate the statistically significant difference in connectivity 
between these two points across the whole brain.  Is there a way to do this 
with “-cifti-math” or the correlation command?  As a corollary, can this be 
performed in FSL / PALM?  This is probably a very basic question, but coming 
from years of SPM8 / SPM12 experience it is not very intuitive…

Any comments, suggestions, or pointers would be much appreciated!

Thank you,

Michael F. Regner, M.D.
Departments of Radiology and Bioengineering
University of Colorado – Denver
E-mail: michael.reg...@ucdenver.edu<mailto:michael.reg...@ucdenver.edu>


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