All,
Has anyone ever used a transit compartment model in NONMEM for PK with
multiple doses. We are looking to use ~25 transit compartments (and
thus ~25 DiffEqs in the $DES block). This seems easier for multiple
doses, compared to the mathematical solution detailed in Rada Savic's
2004 PAGE presentation. We are also trying to implement the gamma
scaling factor in the transit compartment equations (Sun YN, Jusko WJ. J
Pharm Sci. 1998 Jun;87(6):732-7), but it seems to be fairly unstable in
NONMEM. Can anyone comment/help?
Thanks in advance,
Matt
