Hello Tonya,
I was dxed in November 2000 also! I have been on IM
since Jan 2003 after 18 months or so of IFN. am PCRU by nested
PCR.
For a good dissection of a clinical paper looking at BMT
with URD (un-related donors) or with UBCT (Umbilical cord blood) just follow the
link.
Home computers aid disease fight
More than
150,000 home computer users are helping scientists to find new ways to
treat diseases like Alzheimer's.
They are signed up to [EMAIL PROTECTED], a
Congratulations on being
PCRU!
Cheers,
Cheryl-Anne
New! Sign up for local CML support group meetings in your local community at
http://cml.meetup.com
Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes. Loan programs for all
September 21, 2004 08:05
PMUS Eastern Timezone International Leukemia Expert Hagop Kantarjian
Joins ChemGenex Scientific Advisory Board
BIOWIRE2KMELBOURNE,
Australia, MENLO PARK, Calif.--(BUSINESS WIRE)--Sept. 21, 2004--ChemGenex
Pharmaceuticals (ASX:CXS) announced today
Hello Dawn and
Everyone
I am also in PCRU
and feeling rather hopeful about the new drugs in the pipeline too!
However, this isn't stopping me from going ahead with part II of my stem cell
harvest. Part I happened last March and you can read all about it here:
Folks,
This is a bit off
topic, but not. I am delighted to say that I finally heard from my cousin
who just moved (end of July) to the Caymans. With her permission I have
posted some of the contents of her e-mail to me. I had been so worried
about her and Penny. So Penny if you are
Hello
Folks,
First the
disclaimer:
Disclaimer:
These are just my personal notes from having attended this talk and nothing here
is intended to be used as medical advice whatsoever. If you have any
questions related to your particular case, please talk to your doctor. I
am posting my
Gene-Silencing Technique Offers New Way to Fight Drug-Resistant Leukemia
PHILADELPHIA, Oct. 29 (AScribe Newswire)
-- Ever since the approval of Gleevec in 2001, a cancer-cell-specific drug used
to treat chronic myelogenous leukemia (CML), the field of cancer therapeutics
has been rushing
Hello
All,
When I was at the
LLS Dr. Mauro talk in Connecticut I had heard a rumour that there will be more
of these talks in other areas in the US. I also heard that Dr. Nimer will
probably give a talk in the Connecticut area just before ASH, I might attend
that one too since he is my
Hello
Zavie,
Glad you can make it
for the 13th of November. I am organizing this through McGill with Dr.
Laneuville and as I mentioned in my previous message we are on for November
13th, and it is going to be quite fantastic! Hopefully you will have
anyone who wants to join us get in
Cancer News Article
Gleevec is Safe and Effective for
Children with Philadelphia Chromosome-Positive Leukemia
Researchers affiliated with Childrens Oncology Group have reported that
Gleevec (imatinib mesylate) is safe and effective in children with PH+
Hello
All,
We've finally
workedout a link to Dr. Mauro's notes andhe has viewed the link and
has approved.
We know that
anything on the web can be copied, but I hope all of us respect Dr. Mauro's
wishes and just view the notes. This way we will all benefit from being
allowed to do
Hello
All,
Yesterday and this
morning I sent out (by e-mail) invitations, and a "primer" on Basic Cell Biology
to everyone who has expressed an interest in the Montreal Meeting on Saturday,
November 14th. If you haven't received anything from me, then contact me
off list and I will be
Hello
all,
Hopefully those of
you who wanted to access the link to Dr. Mauro's notes during the weekend got
the chance to do so.
http://207.134.71.214/medsummit/
For those that have
read it, here are some of the questions that were asked:
Disclaimer - these
are Q A's from my own
Hello Folks,
Last night I had a chance to look at my
notes from ASH and I am happy to say I have lots and hope to finish posting them
up by this weekend. There is still quite a bit from Sunday's sessions that
I haven't posted but that will be following shortly.
Monday Simultaneous
Hello
All,
There have been some
recent posts about depression so I thought I would post a few links.
Depression is something we all have to deal with at one time or another and
getting help to understand and manage depression is as important as seeing your
Hem/Onc for your CML. Last
Hello All,
Follow the link to an interesting story on stems cells and cancer.
http://www.forbes.com/markets/equities/forbes/2004/1227/070.html
Yahoo! Groups Sponsor ~--
$4.98 domain names from Yahoo!. Register anything.
Published 20 December 2004 as
10.1084/jem.20041306. Rockefeller University Press, 0022-1007/2004/12/1689 $8.00The Journal of
Experimental Medicine, Volume 200, Number 12, 1689-1695
Brief Definitive Report
Role of Dok-1 and Dok-2 in Leukemia Suppression
Hello
Everyone,
I have been playing
around with numbers ever since Dr. Druker said that it is possible at dx to have
one Trillion leukemia cells.
Chronic Myelogenous
Leukemia is a disease of the white blood cells, or granulocytes, that is why
this disease may also be referred to as
Hello
Folks,
Here's some good
news!
Happy
Reading.
Cheers,
Cheryl-Anne
Public release date:
21-Dec-2004[
Print
Article | E-mail Article
| Close
Window ]Contact: Jim Keeley[EMAIL PROTECTED]301-215-8858Howard Hughes
Medical Institute
Researchers discover a stem-cell switch
Hello
Folks,
A little Christmas poem
from me to you. I wish I could have named everyone, but know that you are
all thought
of and have my very best
wishes for your health and happiness this holiday season and through out the New
Year!
Cheers!
Twas the night before Christmas, and
Dear
Folks,
I've spent the
better part of yesterday and today in quiet retrospection, and what I call
"working meditation". I have been preparing my family home and myself or
the New Year. My husband and daughter were gone, so I spent the entire day
going from room to room in my
Hello
All,
Here is an update on
Peter - we must continue to pray for him, it is working! This message was from
late yesterday afternoon, I hadn't checked my other "in
basket".
Warmly,
Cheryl-Anne
Hello everyoneI just heard from
Chris--Peter's procedure went well today. He came out
Hello
Friends,
A dear friend,
Marie, is in the hospital receiving chemo intrathecally (through lumbar
puncture), as blast cells were found in her spinal fluid. Marie was dxed
in 96 with CML and was dxed in blast crisis. Through one small miracle
after another, she went through chemo
Therapies Reduce Resistance to Gleevec Patients With Different
Leukemia Types Benefit
Certain leukemia patients
resistant to the drug imatinib mesylate (Gleevec) can overcome the setback with
two more potent targeted therapies, according to new study results.
The therapies, known as
Blast count and cytogenetics correlate and are useful parameters for the
evaluation of different phases in chronic myeloid leukemia.Bacher U, Kern W, Schnittger S, Hiddemann W, Schoch C, Haferlach
T.Staging of chronic myeloid leukemia (CML)
phases is based on cytomorphological criteria
Hello
Folks,
Jerry Mayfield had
asked us all to pray for his Canadian friend Peter and it happens that I had met
Peter's wife while I was in Toronto, Ontario during the holidays. Peter's
wife Chris, has been keeping me up to date on Peter's status. After our
lunch, Chris returned to
Dane,
You know I will be
joining all your very many listmate friends in wishing and praying forthe
best outcomeson this next step of your journey through this
disease.
I had been really
thinking positively for you that the FTI would work. I like to think that
everything we use against
Posted on Sun, Jan. 09, 2005
Targeted therapies: A quest for miraclesBy Fawn VrazoInquirer Staff
Writer
"I want off," David Wolovitz told his cancer doctor. "I want off
now."
It was the fall of
Title: THE DEVELOPMENT OF IMATINIB AS A THERAPEUTIC AGENT FOR CHRONIC
Hey Folks,
This Sunday afternoon finds me not too far from my fireplace with Bob Dylan's greatest hits playing in the back ground while I review and dissect the white paper below.
I'll be happy to post the entire
Hello
Folks,
So, it is back to
the Monday grind!
I finally finished
going through the above mentioned very long "white paper". The paper will
be interesting for newbie's because it gives a background on the rationale that
lead to the development of Gleevec. It will be interesting to
As per Christine's
message of yesterday, here is the press release as it went out over the
wires. To this I will add that I hear that a trial forAMN107 will
probably start in a couple of months at Hopital Maisonneuve Rosemont in Montreal
which is part of the CHUM (Centre Hospitalier
I will be happy to
get the full article and put it here if anyone would like it. Please let
me know.
Cheers,
Cheryl-Anne
Psychosocial Function After Hematopoietic Stem Cell Transplantation
Grace Chang, M.D., M.P.H., E. John Orav, Ph.D., Tay K. McNamara,
Ph.D., Mei-Yee Tong, M.S., and
From: Neddo Family
[EMAIL PROTECTED]
Subject: Re: Psychosocial Function After
Hematopoietic Stem Cell Transplantation
Cheryl-Anne,
I would like the full article here or you could email
it to me privately.
Thanks,
Barb
Hey Barb,
Give me a couple of days and I'll get it for
you.
Cheers,
Hey
Folks,
This was a good day
for polls. Christine thanks for setting up the poll on weight gain, and
sensitivity to cold along with the questions on the thyroid - last check it
looks like we might be headed into a dead end on the thyroid
link.
I do not know who
created the second
Richard,
I really like your thinking on this, I
have a thought and I'd be happy to hear from you and anyone else on
this.
Much like
you,if I were just starting out on Gleevec treatment today I would
probably like to start at 400mg. My thought was that I would throw in this
Sorry to hear about
everyone's difficulties with wounds and sores. Having worked for a few
years in the area of chronic wounds in the healthcare industry I can understand
your plight. I have stood behind doctors as they have probed into some of
the nastiest chronic wounds you could ever
Early trial may point way to overcoming imatinib resistance
Eighty-six percent of patients achieved a complete hematologic remission
after imatinib resistance.
By Tammy DottsManaging Editor
January 2005
---Charles Sawyers, MDPhoto courtesy of ASH
SAN
Generation Next for CML
Despite a good response to imatinib, many patients remain positive for
Bcr-Abl transcripts.
By Brian J. Druker, MDSpecial to Hem/Onc Today
January 2005
---Brian J. Druker, MD
Once again, at this yearÂ’s American Society of
Latest News on Chronic Myelogenous Leukemia - The Leukemia Lymphoma
Society24 Jan 2005
Free,
Interactive Telephone Program Presents Update from the American Society of
Hematology Annual Meeting - WHITE PLAINS, NY - Michael J Mauro, M D, an
expert on
Compound Might Aid Leukemia
Patients Resistant to Gleevec
By Amanda
GardnerHealthDay Reporter bBy Amanda
Gardner/bbriHealthDay
Reporter/i,
WEDNESDAY, Jan. 26 (HealthDayNews) -- Scientists have developed a compound
that may be able to treat cases of chronic myelogenous leukemia that
Norwood Immunology Limited Announces IND For Bone Marrow
Transplant Treatment Has Been Accepted by FDA
Trial performed in
conjunction with prestigious consortium of cancer specialists, co-funded by
National Cancer Institute and the National Institute of Allergy
Hello
Folks,
My younger sister in
Pennsylvania passed this e-mail along to me and since we talk about the breast
cancer here once in a while, I thought it would be good to send this
along. Please take the time to sign the petition, this group knows the
power of petitions!
Please take
Hello
Folks,
4th point
under Company Highlights talks about the use of the above named drug in Phase 1
II clinical trials for CML patients who have failed all other
therapy.
Good
Reading!
Cheryl-Anne
Cytokinetics, Incorporated Reports Fourth
Quarter and Year End 2004 Financial
Very interesting
article posted to CMLTalk.
Good
Reading,
Cheryl-Ann
New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com
Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry lenders in just minutes.
Representatives, Scientists, Cord Blood Transplant Recipients
Call On House Legislators to Pass H.R. 596
2/7/2005 3:46:00 PM
To: National Desk, Political and Health Reporters
Contact: Rich Miller-Murphy of New York Blood Center, 212-570-3101,
917-439-1727; Gladwyn Lopez of Rubenstein
I thought this would be of
interest to some. Kaposi's Sarcoma is a very debilitating disease which
usually strikes in late stage AIDS patients. When I was working in Chronic
wound care we saw some of the lesions caused by this disease.The
stigma associated with it is just heart
Hello
Folks,
More details on the
meeting of March 19th in Montreal.
The First
Canadian Forum for Patients with Chronic Myeloid Leukemia (CML)
will be held in the afternoon of March 19th, 2005 - Saturday at the Centre
Mont Royal in Montreal QC.
Dr. P. Laneuville
will present the
Hello
Folks,
More details on the
meeting of March 19th in Montreal.
The First
Canadian Forum for Patients with Chronic Myeloid Leukemia (CML)
will be held in the afternoon of March 19th, 2005 - Saturday at the Centre
Mont Royal in Montreal QC.
Dr. P. Laneuville
will present the
New
vaccine may help fight leukaemia - study
Fri February 18, 2005 6:28 AM GMT+05:30
LONDON (Reuters) - An experimental vaccine that boosts the immune
system has produced good results in treating patients with chronic myeloid
Hello
Folks,
Here's another
report on that vaccine:
Reported February 22,
2005
Vaccine may Improve Leukemia Treatment
(Ivanhoe Newswire) -- A vaccine that stimulates immune response could boost
the effectiveness of conventional treatment for patients with chronic myeloid
leukemia,
Hello
Folks,
This looks pretty
credible and quite exciting.
Plant derivative attacks the roots of leukemia
A daisy-like plant known as Feverfew or Bachelor's
Button, found in gardens across North America, is the source of an agent that
kills human leukemia stem cells like no other
Actually, I hope everyone knows that they should not
take any herbal medicines without verifying with your doctor. This is
exciting news, but we have to wait until the research is finished. The
Feverfew that you can buy from a herbalist is not in the appropriate form to
treat Leukemia.
Hello
Rob,
Sorry to read about
the extent of the harassment you've been enduring through Yahoo. I can't
imagine why people would want to do this to other people. It is very sad
that you've been banned from Yahoo.I hope we can keep things going
until we are finished with the project of
Dr. Pierre Laneuville, Director, Hematology, MUHCUpdates on CML
treatment Guidelines
Mr. Rudy Putns, CEO, Leukemia Lymphoma Society of CanadaNew Mandate of
the LLS in Canada
Cheryl-Anne Simoneau, CML patient patient
advocatorPresentation and launch of
website for CML patie
February 28, 2005 09:00
AMUS Eastern Timezone NCCN Releases Acute Myeloid Leukemia and
Chronic Myelogenous Leukemia Chapters of the NCCN Drugs Biologics
Compendium
BIOWIRE2KJENKINTOWN,
Pa.--(BUSINESS WIRE)--Feb. 28, 2005--The National Comprehensive Cancer Network
Child with rare illness hopes to beat the
odds
By MIKE KALIL Reformer
Staff
SPOFFORD, N.H. -- Three-year-old Hristianna Lanoue
doesn't look sick, but she has a rare illness.
Her chronic myelogenous leukemia -- which seldom strikes children -- is rare
enough that doctors don't know how
Vaccine for Chronic Myeloid Leukemia Highlighted in Lancet
Publication; Vaccine Significantly Improves Molecular Remission Rate of Patients
with Persistent CML
GREENWICH, Conn.--(BUSINESS WIRE)--Mar 1, 2005 - Breakthrough Therapeutics, a
privately owned biotechnology company, today
The latest
information says that it works on AML and Blast Crisis CML cells, considering
these two are quite aggressive, this is rather hopeful news for all of
us.
Plant
Derivative Kills Leukemia Cells
NEW YORK MAR 01, 2005 (Reuters Health) - Parthenolide, a chemical that is
derived
Hello Folks,
This
isprobably more relevant for the Yahoo list than the Google list.
The person who has
cleverly figured out how to send viruses using Richard R's e-mail address is
also sending messages to people privately with viruses
attached.
Please be
aware.
Last night when
Hello
Everyone,
March 17 is fast
approaching! Alan Hobson is all set to arrive in Montreal and encourage us
all on our journey with his awe inspiring pictures of his trek up Mt. Everest
and the parallel of that adventure with going through a SCT for
AML.
Thanks to the
generosity of
Hello
Everyone,
In November 2002 I
joined the Yahoo list after going through 2 years of having CML without feeling
the need to participate in such a group.
I joined for two
reasons,the first reason was a horrible event that had happened to a very
good friend. Her name was Tanya
I could not have
imagined how many responses I have received concerning my post about my friend
Tanya.
Thank you all for
your kindness and support. This was aquiet weekend and I focused on
letting her go, but keeping her memory in my heart, not an easy thing to
do.
It has been a
Dear Everyone,
This has been an interesting discussion in that we are finding out what goes
on behind the scenes with this list and probably what we can expect to
happen on any other list.
If I am understanding this all correctly, we have people writing to Rob
asking him to put better rules
Cross
Posted
This news tidbit
highlights the very innovative use of nanotechnology in helping researchers to
screen compounds as drug candidates.
Good
reading!
Cheryl-Anne
Nanowires track molecular
activity
As molecules go, DNA and
Cross Posted
Heads up! New kinase inhibitor targeting BCR-ABL
- Dr. S. Nimer on the is part of the development
team.
Cheers,
Cheryl-Anne
Dr. Jerome
Groopman Chairs Onconova Therapeutics Inc. New Clinical Advisory
Board
BIOWIRE2K
PRINCETON,
N.J.--(BUSINESS
ChemGenex
Launches Multi-Center Phase 2 Clinical Trial of Ceflatonin in Combination with
Gleevec in Patients with Chronic Myelogenous Leukemia MELBOURNE,
Australia MENLO PARK, Calif.--(BUSINESS WIRE)--April 7, 2005--ChemGenex
Pharmaceuticals Limited (ASX:CXS) announced today that it has
Hello
Folks,
This is NEW
information on how CML cells DO NOT crowd out healthy cells, as was long thought
to be the case, but actually kill them. While this sounds like it is bad
news, it is good news as it sheds new light into this area and paves the way for
science to work on the
More interesting
news!
Cheers,
Cheryl-Anne
Next-era targeted therapy overcoming Gleevec's shortcomings
Anaheim, Calif. -- Though Gleevec has shown "wonder
drug" capabilities for treating chronic myelogenous leukemia and other cancers,
experience in treating patients has revealed some
Hi
Everyone,
Suzan and I were at
the New Horizons in Cancer treatment conference in Ireland and will be providing
an update in the next post. Here's a nice article that appeared in today's
Montreal Gazette.
Cheers,
Cheryl-Anne
Motivation is in her blood now
Suzan McNamara refused to
Hey
Folks,
I am back from a
nice vacation on board a boat in Lake Champlain, and I am lucky enough to be
able to plan a second vacation of the same genre at the end of this
month.
Hope everyone has
been well.
Here's an
interesting article regarding BMT's.
Cheers,
Cheryl-Anne
Update from Novartis
news release on AMN107
This excerpt was
taken from a lengthy press release regarding Novartis's other drugs for Diabetes
and cardiovascular health. Rather than post the entire article, I thought
I'd just send the paragraph that regards CML...
Cheers,
Cheryl-Anne
Glioblastoma Multiforme is a
very aggressive form of brain cancer with avery poor prognosis for
patients. I think some members of this list and the other list had been
asking if IM works on this type of cancer. The results of this study seem
really promising.
Best,
Cheryl-Anne
This was from an Australian
News paper, it is likely that the Phase II has also started here. I think
this drug was at MD Anderson and we've talked about it
before.
Biotech firm starts
drug trials
October 5, 2005 - 1:59PM
Biotechnology firm ChemGenex Pharmaceuticals Ltd has
started a
Dear Friends and
fellow CMLer,
Exciting news - we
are finally able to confirm that we will have a very special meeting on October
29th at the Royal Victoria Hospital - J.S.L. Browne Amphitheatre, on October
29th, 2005. It will start at approximately 1:00 PM with a lunch and other
Leukemia Under the Microscope
By AMBER HSIAO
Contributing Writer
Wednesday, November 2, 2005
In a recent study, UC Berkeley researchers were able to use bone marrow
samples in order to analyze differences related to childhood leukemia. The
marrow samples contain a shortened version of a
CML Patient Meeting October 29, 2005
Hello Everyone,
This is a very long
post.
As promised, I am happy to provide a summary
of the meeting.
First of all, it just wouldnt be a meeting without the people who take
time and join us. We were about 40
patients, family/friends. Thank you
Hello
All,
As promised here is
part II
Before getting into
part II I did want to mention another milestone that was celebrated at our
meeting.
We all signed a card
and celebrated Suzan McNamara's birthday. A significant date for us all -
since it was also the date 6 years ago that
not
hesitate to contact me if you have questions or need special
arrangements.
Cheers,
Cheryl-Anne
Simoneau
New! Sign up for local CML support group meetings in your local community at http://cml.meetup.com
Apply for Commercial Real Estate loans online and submit your deal to dozens of hungry
Hello
All,
Today marks my 5th
anniversary of diagnosis with CML. Much like today, I greeted that day
five years ago with anticipation of the day's celebration even though I was not
feeling well. A side trip to the hospital for a totally un-related event
led to a not so routine blood
Hello
All,
Iwas reading
through the posts and noticed that there are new younger patients
here.
Some of you might be
interested in this abstract that will be presented at
ASH (American
Society of Hematology) this year. I will be going to ASH so, I will be
happy to report back.
Happy
Prescription Ills
Seniors in managed-care plans may pay much more for drugs
Rosalie Gregory sits in her kitchen, trying to figure out how she is going
to be able to afford co-pays for her leukemia medication under the new
senior drug plans.
MARTY BICEK/THE BEE
By KEN CARLSON
BEE STAFF
Hello
All,
Just thought I would
chime in on this. While I thoroughly agree with what has been written on
the subject -CML is not in and of itself a hereditary disease, I thought
you would be interested in knowing that I know at least three (3) fellow CMLers
who all lost their fathers to
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