[NMusers] IIV on %CV-Scale - Standard Error (SE)

2008-02-15 Thread Ribbing, Jakob
Hi all, I think that Paul stumbled on a rather important issue. The SE of the residual error may not be of primary interest, but the same as discussed under this thread also applies to the standard error of omega. (I changed the name of the subject since this thread now is about omega) I

RE: [NMusers] enzyme turnover

2008-02-15 Thread John Lukas
Khaled, You seem need another parameter. KENZ cannot be both a creation and a death rate for A(3) (i.e. [mg/h] and [1/h]). Also, it is confusing the way you use both masses and concentrations in your interaction terms. Do you intend CL24 to be L h-1 mg-1? John John C Lukas Strategic

RE: [NMusers] IIV on %CV-Scale - Standard Error (SE)

2008-02-15 Thread Mouksassi Mohamad-Samer
Hello Jakob, I remember I developed code at one point to calculate a SE on a typical clearance which was a function of four covariates.. The general method is to use formula incorporating partial derivatives with respect to each parameter.

RE: [NMusers] IIV on %CV-Scale - Standard Error (SE)

2008-02-15 Thread Ken Kowalski
Hi Jakob, The derivation for your expression comes from a first-order approximation of the variance often referred to as the delta method in the statistical literature. The approximation is: Var(f(x)) ~= [f'(x)^2]Var(x) or equivalently, SE(f(x)) ~= f'(x)SE(x) If we want SE(omega) but have the

Re: [NMusers] IIV on %CV-Scale - Standard Error (SE)

2008-02-15 Thread Leonid Gibiansky
Jakob I am not sure that the formula that you present is correct: sqrt(SE.OMEGAnn)/(2*sqrt(OMEGAnn))*100% I think, you do not need to take sqrt(). This is what I would use SE.OMEGAnn/(2*OMEGAnn)*100% Note that your S-plus function also does not take a sqrt, so it could be just a typo.

[NMusers] Combined residual model - reporting of sigma and sigma squared

2008-02-15 Thread Paul Westwood
Dear All, Thankyou to all that replied to my email concerning the combined mixed residual model, and thanks to Leonid for the changes in the $ERROR code. I have one final question regarding the reporting of the thetas and the sigmas. Why, when you use thetas in the residual error structure