Sorry for my previous misapprehension of your sample.

Try this:

Find:
U(?=[^a-z])|(U(?=[ACGT]+?))

Replace:
\1T

The first part U(?=[^a-z0-9]) is to eliminate the 'U' in the '>' line. NOTE: this assumes that those 'U's are always followed by a lower-case letter or a number.

The second part finds any 'U' followed by one or more of any of 'A, 'C', 'G', or 'T'.

Without that first part, the second part of the match will catch all but a 'U' at the end of the line.

HTH

On 4/12/20 at 8:01 AM, achim.quai...@gmail.com (archaeal) wrote:

Hello,
I would like to detect the lines starting with >.+ and replace all U with T in the following line, but not in the line starting with >
Example:

NeiUe166        1551 bp          rna
AGAGAUUGAACAUAAGAGUUUGAUCCUGGCUCAGAUUGAACGCUGGCGGCAUGCUUU
Unc31652        1491 bp          rna
AGGGUUUGAUCAUGGCUCAGGACGAACGCUGGCGGUGCGCCUUAUGCAUGCAAGUCG
Unc31653        1469 bp          rna
AGGGUUUGAUCAUGGCUCAGAACGAACGCUGGCGGCAUGCUUCAGACAUGCAAGUCG

should look like:
NeiUe166        1551 bp          rna
AGAGATTGAACATAAGAGTTTGATCCTGGCTCAGATTGAACGCTGGCGGCATGCTTT
Unc31652        1491 bp          rna
AGGGTTTGATCATGGCTCAGGACGAACGCTGGCGGTGCGCCTTATGCATGCAAGTCG
Unc31653        1469 bp          rna
AGGGTTTGATCATGGCTCAGAACGAACGCTGGCGGCATGCTTCAGACATGCAAGTCG

The search pattern should find the >.. line but make changes only in the next line Another possibility would be to search just in the "second" line for U and replace with T

It would be great if someone has an idea.

Thanks a lot
archaeal


--

  - Bruce

_bruce__van_allen__santa_cruz__ca_

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