Öznur Tastan wrote:

The result is (12+5)-(1+4) or 12?

I didn't exactly understand this line but if you are alignment of L E can be 17 (though not very likely because they are not that similiar aminoacids:) but AD - - will be definitely negative since the both A and D is aligned with gaps that will be penalized. if a linear gap penalty scheme is used and say the gap penalty is -5 the score of the alignment will be -10

A-Z = 1-26


L = 13 + E = 5
______________
    17

So you see where my confusion is coming from.
-Sx-

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