For BLFS editors, DESTDIR is usually useful when testing and measuring a package - for a few, it still needs to be run as root, for others, particularly using QT, it needs a variant (check the wiki pages - I have made notes in some of them), and for a very few other packages it does not work at all. Because we do this, we can add notes as things become apparent.
My only significant variations so far have been for Xorg Server and DBus, due to the SUID requirements. So to maintain the user based scheme I did a DESTDIR install in the package user's home directory. Then as root, I sym-linked everything to the root file system and changed the owner as necessary.
User based management has turned out to be a great learning tool as well.
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