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Dear all, I am currently refining the structure of a protein-DNA complex using Refmac. Is there a possibilty to set unequal values of the weighting term for the protein and the DNA? And in addition to that, can I tell Refmac to take the base pairing in the dsDNA into consideration, although the helix does not represent ideal B-DNA, but shows a relatively strong distortion? Thank you very much in advance. Best regards, Kristina
