Typically crystals of small organic compounds do not require freezing as
there are no solvent channels. They do in general not suffer from
radiation damage at room temperature the way protein crystals do.
Occasionally they are mounted in a capillary instead of simply glueing
them to a goniometer if they are air sensitive. In principle freezing
should not damage the crystals, but one still may have to be carefull if
the crystals are large. I think you risk increasing mosiacity, and any
manipulation that is not needed will on average only reduce the quality
of the specimen rather than improve it
Remy Loris
Vrije Univesiteit Brussel
Jayashankar wrote:
Dear Scientists and Friends,
I am not sure, whether organic crystals need to be in cryo stream
necessarily during data collection from an in house
xray machine .
How most of the organic crystals have been solved mostly?
--
S.Jayashankar
(A bit confused new generation researcher).
Research Student
Institute for Biophysical Chemistry
Hannover Medical School
Germany
