But you have to do solvent flattening (density modification), which people often (unintentionally?) skip for structures solved with molecular replacement. Please correct me if I am wrong.
Clement On May 24, 2011, at 6:01 PM, [email protected] wrote: > This is not my experience. Provided the solvent is featureless, I find > that a high solvent contents leads to a lower Rfree due to a kind of > solvent flattening effect. Of course, if a significant part of the > molecule(s) is/are disordered, this will lead to a degradation of the > Rfree. > > My 2 cents, > Herman
