> I suspect that there was a time when the anomalous signal in data sets was > fictional. > Before the invent of flash freezing, systematic errors due to decay and the > need > of scaling together many derivative data sets collected on multiple crystals > could render > weak anomalous signal useless. Therefore MIR was needed. Also, current > hardware/software > produces much better reduced data, so weak signals can become useful.
I think that weak beam intensities (home sources), large crystals, big HA signals (f" = ~12 @ CuKa for some Lanthanides), and high symmetries could all make measuring anomalous signals much easier even without cryo. And...Phil Evans did it! JPK ******************************************* Jacob Pearson Keller Northwestern University Medical Scientist Training Program email: [email protected] *******************************************
