Classical case would be Hexokinase. Also, try the various states of Fatty Acid Synthase.
Reza Khayat, PhD Assistant Professor The City College of New York Department of Chemistry, MR-1135 160 Convent Avenue New York, NY 10031 Tel. (212) 650-6070 ---- Original message ---- >Date: Thu, 27 Feb 2014 19:43:01 +0000 >From: CCP4 bulletin board <[email protected]> (on behalf of "Keller, Jacob" <[email protected]>) >Subject: [ccp4bb] Large Conformational Change Upon Binding Ligand... >To: [email protected] > >Dear Crystallographers, > >Does anyone know of good examples of large, reversible conformational changes occurring between ligand-free and - bound states? Could also be a non-relevant molecule binding, like sulfate or something inducing dubiously -relevant changes. I already know of the calmodulin and periplasmic binding protein families, but does anyone know of others out there? > >All the best, > >Jacob Keller > >******************************************* >Jacob Pearson Keller, PhD >Looger Lab/HHMI Janelia Farms Research Campus >19700 Helix Dr, Ashburn, VA 20147 >email: [email protected] >*******************************************
