Hi Sergei We did some data-mining on this way, way back, in 2004.
See the second section in this link https://www.douglas.co.uk/PDB_data.htm When you consider the *non-standard *temps - ie NOT 4C or 20C - it *looks* as though the higher-end temps *may *work better. But of course it's hard to make sense of the results of a martingale. Thx Patrick PS Janet (Newman) do you have anything more up-to-date on this? On Thu, Aug 1, 2019 at 10:24 AM Sergei Strelkov <[email protected]> wrote: > Dear all, > > > I wondered if someone could point me to a recent study on the importance > of temperature during initial search for crystallization conditions. It > would be interesting to see any real statistics on this subject. > > > We typically try to perform screening at at two temperatures, such as > duplicating a given kit screen at 20C and 4C if there is enough sample. My > 'gut feeling' is that this is not as important as sampling the chemical > space though. > > > Thank you! > > Sergei > > > Prof. Sergei V. Strelkov Laboratory for Biocrystallography Department of > Pharmaceutical Sciences, KU Leuven O&N2, Campus Gasthuisberg, Herestraat 49 > bus 822, 3000 Leuven, Belgium Phone: +32 16 33 08 45, mobile: +32 486 29 41 > 32 Lab pages: http://pharm.kuleuven.be/Biocrystallography > <http://pharm.kuleuven.be/anafar> > > > ------------------------------ > > To unsubscribe from the CCP4BB list, click the following link: > https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1 > -- [email protected] Douglas Instruments Ltd. Douglas House, East Garston, Hungerford, Berkshire, RG17 7HD, UK Directors: Peter Baldock, Patrick Shaw Stewart http://www.douglas.co.uk Tel: 44 (0) 148-864-9090 US toll-free 1-877-225-2034 Regd. England 2177994, VAT Reg. GB 480 7371 36 ######################################################################## To unsubscribe from the CCP4BB list, click the following link: https://www.jiscmail.ac.uk/cgi-bin/webadmin?SUBED1=CCP4BB&A=1
