Dear All,

We are trying to solve a structure of a protein, for which we have
collected five different home source data at 3.2-3.5 Ang resolution. We are
processing the data using iMOSFLM and the program suggests P3 (and related)
space groups for all the data. We are able to get a solution with one data
(twinned) in C2 space group with Rw/Rf of 26/28%. However, the same
solution can not be obtained using other four data. Interestingly, one of
these four data is not twinned. The only common thing in these four data, I
find, is that they are crystallized in the same crystallization condition,
whereas, the data which gives solution is crystallized in another condition.

The template has 69% sequence identity with the target protein.

Any suggestion to troubleshoot this would be appreciated.

With best regards,
Suraj

-- 
*Suraj Kr. Mandal*
Research Scholar
Structural and Computational Biology Lab
Department of Biosciences and Bioengineering
Indian Institute of Technology (IIT), Guwahati
Guwahati, Assam 781039
Ph.: 09678244566
E.mail: [email protected]
           [email protected]

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