There is a few Fortune 500 companies in this list of Breeze users: http://www.macromedia.com/software/breeze/customers/list.html
Breeze is marketed towards the Enterprise market and it's doing well.. it's a stable product over a large number of connections, the ability to add custom "pods" to the interface is useful and the future benefits of integrating well with Flex, all justify the investment for the larger company. Have a look at the HP Vision for Next Generation Communications http://www.macromedia.com/resources/telecom/hp_demo/. While Flex 2.0 will be dramatically less of an investment to the general market, it's important that Adobe keep focusing on the Enterprise market because the revenue allows them to keep funding R&D that leads to such great products. Eventually after these products start recouping the investment spent on them, Adobe can start dropping the prices and making them more available to the average business, the cost of developing Breeze n Flex couldn't have been too cheap. We'll all experience the rewards of this when Flex 2.0 launches = )
