As stated before, the gene for hemophilia is an example of a sex linked gene.
It is only found on the X chromosome.  It is very very rare in females
because it is rare for a female to have a hemophiliac father (he would have
to have the defective gene on his X chromosome and would need to live to a
reproductive age) and a carrier mother (one who has the defective gene on one
of her X's) .  This female offspring would have to be very unlucky.  There
would be a 50/50 chance of her being afflicted. From her father she would
inherit the only X chromosome he has, but from her mother she could get
either of the X chromosomes ... the one with the "good" gene or the one with
the "bad"gene.

Sometimes, more frequently with older women, a chromosome does not split
properly and the infant will get an extra chromosome.  When this happens it
is called a tri-somy. (three chromosomes inherited by the infant instead of
the usual two). When this happens with the 21st chromosome the offspring will
exhibit Down's Syndrome.  Other defects are caused by trisomy conditions with
other chromosomes.

Pat

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