Leanne answered this much better than I can, but I would think that you should say that your friends dogs don't display it. I suspect that this is equivalent of what the worst case scenario of the Cavalier thrombocytopenia would be. It would be like 100% of Cavaliers being born with asymptomatic, idiopathic thrombocytopenia and a good percentage of them developing the symptoms of the disease later. That is why it is important to test for thrombocytopenia, so that you don't inadvertently breed the trait into all of your dogs. Nothing ever stays the same in genetics, if all the breed were homozygous for the trait, there would be many more who are affected and not asymptomatic.
One thing to note about the Dalmatian problem, it is linked genetically to the desired spotting pattern. That's why it permeated the breed. Breeders bred for a conformation ideal and some bad stuff came with it genetically. This is similar to the Russian fox breeders who wanted better temperament in the foxes as they were so nasty that they were difficult to handle at the fur farms. The result after 10 generations was a fox that no longer had the desired fur and looked like a dog. This is in the latest ACKCSC newletter. Genes for single traits are qrouped in chromosomes. When you breed for a single obvious trait, you get all the genes that are carried on the chromosome with that trait--- some good, some bad. All the best, Susan Cochran ----- Original Message ----- From: "Peggy Mickelson" <[EMAIL PROTECTED]> To: <[EMAIL PROTECTED]> Sent: Tuesday, January 29, 2002 12:38 AM Subject: Re: [CKCS-L] more on genetic diversity > well, susan, all i can say is that you should read all the stuff i said,,, and > then ask joanne nash. my friends with dalmatians do test for that problem but > none of them have it. or should i say, display it??????? > peggy > > > Susan Cochran wrote: > > > You mentioned that "A small gene pool is only a problem if every single dog > > in the breed > > has, and is "pure for," the exact same genetic problem. I'm not sure this is > > even possible, much less if it has ever happened in a breed." > > > > That's why I mentioned Dalmatians. Hasn't it been found that the whole breed > > has the genetic problem with uric acid? Some are asymptomatic, but still > > homozygotes for the trait. There was some controversy about it several years > > ago. I think Joanne Nash knows all about it, at least that is where my > > information comes from--- her website. > > > > All the best, > > Susan Cochran > > > > ----- Original Message ----- > > From: "Peggy Mickelson" <[EMAIL PROTECTED]> > > To: <[EMAIL PROTECTED]> > > Sent: Monday, January 28, 2002 11:55 PM > > Subject: Re: [CKCS-L] more on genetic diversity > > > > > what about them? > > > > > > > > > Susan Cochran wrote: > > > > > > > What about Dalmatians and uric acid? > > > > All the best, > > > > Susan Cochran > > > > > > > > ----- Original Message ----- > > > > From: "Peggy Mickelson" <[EMAIL PROTECTED]> > > > > To: <[EMAIL PROTECTED]> > > > > Sent: Monday, January 28, 2002 9:33 PM > > > > Subject: [CKCS-L] more on genetic diversity > > > > > > > > > > No breeding philosophy is any better or worse than the person > > practicing > > > > > > it. No matter whether you outcross, inbreed or do a little of both, > > if > > > > > > you don't know what you're doing, and you don't know how to select > > from > > > > > > what you produce, you will never be successful for longer than can > > be > > > > > > accounted for by sheer luck. > > > > > > Item # 1504941848Even genetic traits that breeders are selecting FOR > > are not > > > > > > completely consistent across a breed. > > > > > > Some breeds have been around for a VERY long time and have gone > > thru > > > > > > bottlenecks and not had much of a gene pool, yet the breed keeps > > > > trucking > > > > > > along. > > > > > > > > > > ========================================================= > > > > > "Magic Commands": > > > > > to stop receiving mail for awhile, click here and send the email: > > > > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL > > > > > to start it up gain click here: > > > > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL > > > > > > > > > > E-mail [EMAIL PROTECTED] for assistance. > > > > > Search the Archives... > > http://apple.ease.lsoft.com/archives/ckcs-l.html > > > > > > > > > > All e-mail sent through CKCS-L is Copyright 2002 by its original > > author. > > > > > > > > ========================================================= > > > > "Magic Commands": > > > > to stop receiving mail for awhile, click here and send the email: > > > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL > > > > to start it up gain click here: > > > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL > > > > > > > > E-mail [EMAIL PROTECTED] for assistance. > > > > Search the Archives... http://apple.ease.lsoft.com/archives/ckcs-l.html > > > > > > > > All e-mail sent through CKCS-L is Copyright 2002 by its original author. > > > > > > ========================================================= > > > "Magic Commands": > > > to stop receiving mail for awhile, click here and send the email: > > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL > > > to start it up gain click here: > > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL > > > > > > E-mail [EMAIL PROTECTED] for assistance. > > > Search the Archives... http://apple.ease.lsoft.com/archives/ckcs-l.html > > > > > > All e-mail sent through CKCS-L is Copyright 2002 by its original author. > > > > ========================================================= > > "Magic Commands": > > to stop receiving mail for awhile, click here and send the email: > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL > > to start it up gain click here: > > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL > > > > E-mail [EMAIL PROTECTED] for assistance. > > Search the Archives... http://apple.ease.lsoft.com/archives/ckcs-l.html > > > > All e-mail sent through CKCS-L is Copyright 2002 by its original author. > > ========================================================= > "Magic Commands": > to stop receiving mail for awhile, click here and send the email: > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL > to start it up gain click here: > mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL > > E-mail [EMAIL PROTECTED] for assistance. > Search the Archives... http://apple.ease.lsoft.com/archives/ckcs-l.html > > All e-mail sent through CKCS-L is Copyright 2002 by its original author. ========================================================= "Magic Commands": to stop receiving mail for awhile, click here and send the email: mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20NOMAIL to start it up gain click here: mailto:[EMAIL PROTECTED]?body=SET%20CKCS-L%20MAIL E-mail [EMAIL PROTECTED] for assistance. 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