Thanks Dianne for your concern and suggestion but I'm just too afraid to. My numbers are climbing again, and I'm assuming with the diarrhea being as severe as it is, not much Gleevec is remaining in my system anyway. My doctor who is a cml specialist with a 30 year practice advises me to take any dose I can a day(I'm prescribed 600mg which I cannot tolerate) whether it be the 600mg, 400mg or 200mg....just keep any and all I can in my system. I do split my pills up with 2 meals and I haven't lowered myself from the 400mg. I take them every day whether they make me sick or give me diarrhea or not. My main problem is I have no appetite whatsoever. I've tried 2 different kinds of meds to stimulant my appetite, neither worked. I have to literally force down what I do eat, and a lot of times it makes me sick. I have always been a big eater but once I started the Gleevec, my appetite and love of food was gone. I guess I am an exception to all the rules of Gleevec. I think if I could keep more food in my stomach, I could tolerate the Gleevec better. I also believe if I could rid my life of any and all stress I would respond better....however, I don't see myself ever being stress free. My husband is in bad health, my sister-in-law is battling cancer, my son is just hopeless, I'm trying to survive on a fixed income that stays the same while gas, groceries, and everything else I could name goes up every day. I really do believe that stress is responsible for the cml in the first place and I think stress is hindering me in some way of responding to the Gleevec. I also think a combination of Gleevec and stress has done something to my stomach, intestines and/or digestive system. I maybe wrong....but I have always had a raging appetite and ate good all my life UNTIL Gleevec. It doesn't take a doctor to tell me that much. I'm just trying to hang on until the new drug comes out whenever that may be and pray my body will be tolerant of it. And hope that maybe I can return to work and live a little easier than I am now financially. I'm only 44....I've got several more years I could work if health permitted me to. Love, Peace, Hope & Prayers, Pat
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