I have heard some can lower the dose while others cannot. It may depend on how responsive the CML was.
There has been some discussion that for people who started on higher than 400 mg doses for the first year or so might benefit from a lower dose in terms of quality of life. The speculation is that the amount of CML has been vastly reduced so less Gleevec is needed to control the leukemia cells. However, other doctors have theorized that this might allow the CML to "escape" drug control and let it mutate to a more resistant form. Gleevec-resistant cell lines used in lab studies are often developed by using an approach of below minimum dosing regimens. Further confounding the analysis is that the level of Gleevec in the blood can vary among humans quite a bit. Its going to take some brave volunteers in a clinical trial to answer that question. Weight or height is not thought to be relevant to Gleevec blood levels. I think it might tend to do with how active you liver is at breaking down the Gleevec or other medications that are taken on the same day that can effect the liver's processing of Gleevec. --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
