Sheila, FDA still only allows Sprycel and Tasigna to be prescribed after Gleevec has been tried first. That will probably change in the near future, since several studies have shown they would all be effective as first-line therapies for CML. http://www.eurekalert.org/pub_releases/2007-12/uotm-dns120707.php
Regarding side effects, there is a recent article that has a good side- by-side comparison of the 3 drugs: http://www.hemonctoday.com/article.aspx?rid=30195 This shows that Sprycel does not cause the muscle cramping or rash problems that Gleevec has as side effects. But Sprycel can be harder on the liver, can cause lower phosphate levels (necessary for electrolyte balance and good bone health), and has worse fluid retention issues (including fluid build-up in the lungs) compared to Gleevec for some people. Gleevec causes worse bone and muscle pain. Tasigna seems to have the lowest overall side effects unless a person has some specific heart related issues. But overall, these side effects can vary from person to person. Generally I would not be afraid of Sprycel, but you should review the comparison for yourself and let your Onc know what you prefer. --~--~---------~--~----~------------~-------~--~----~ [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [EMAIL PROTECTED] For more options, visit this group at http://groups.google.com/group/CMLHope -~----------~----~----~----~------~----~------~--~---
