Sorry but I'm not understanding why you switched drugs if you were CCR on the gleevec. I would stick with the one that had the less side effects. Just staying alive is more important to me than reaching the Big Zero and the Gleevec has done that for you. Just my 2 cents...my situation is totally opposite of yours.
On Mar 15, 12:03 pm, Sean <[email protected]> wrote: > Hello all, > > Been a long long time since I last wrote to this group. Thought I'd > check in. I was dxd in Oct 2002 when I was 21 years old. My WBC at > time of diagnosis was 498,000. Since that time I've been on Gleevec > for the first 6.5 years or so (between 400 - 800mg but mostly the > latter), and I've been on Sprycel for the past year, first at 140mg > and now at 170mg. I'm young, so I suppose that helps me tolerate the > high doses, as I had virtually no problems on Gleevec for all those > years other than minor fluid retention in the ankles. I've been CCR > for a long time but guess I forgot to tell Zavie about that :) > > My PCR tests have been hovering between 0.08% (8x10^-4)and lower, the > most recent at 0.0012% (1.2x10^-5). The switch to Sprycel was an > effort to get to PCRU, but now I've got pleural effusion. It's not > particularly noticeable, but chest x-ray confirmed it along with > increased shortness of breath climbing stairs, etc. Doc said to switch > to 170mg 6 days/week instead of 7. If this doesn't work he may want to > switch me to nilotinib, but that doesn't sound like a fun drug to me. > > Question is: Is PCRU really that worth it? I think I'd rather stay on > a lower dose of Sprycel, rid myself of the fluid as a result, than > switch to yet another drug. The PCR results are already really low. > > Thoughts? > > Hope everyone is doing well, > Sean -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope
