Hello all, Been a long long time since I last wrote to this group. Thought I'd check in. I was dxd in Oct 2002 when I was 21 years old. My WBC at time of diagnosis was 498,000. Since that time I've been on Gleevec for the first 6.5 years or so (between 400 - 800mg but mostly the latter), and I've been on Sprycel for the past year, first at 140mg and now at 170mg. I'm young, so I suppose that helps me tolerate the high doses, as I had virtually no problems on Gleevec for all those years other than minor fluid retention in the ankles. I've been CCR for a long time but guess I forgot to tell Zavie about that :)
My PCR tests have been hovering between 0.08% (8x10^-4)and lower, the most recent at 0.0012% (1.2x10^-5). The switch to Sprycel was an effort to get to PCRU, but now I've got pleural effusion. It's not particularly noticeable, but chest x-ray confirmed it along with increased shortness of breath climbing stairs, etc. Doc said to switch to 170mg 6 days/week instead of 7. If this doesn't work he may want to switch me to nilotinib, but that doesn't sound like a fun drug to me. Question is: Is PCRU really that worth it? I think I'd rather stay on a lower dose of Sprycel, rid myself of the fluid as a result, than switch to yet another drug. The PCR results are already really low. Thoughts? Hope everyone is doing well, Sean -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope
