Hi Pat,

I've been on Sprycel in a clinical trial since 2005. Although I take my 100 mg in the morning, I've never been told to take it at any particular time of day. I don't have the headache problem either. However, I have just returned from a meeting of some CML patients where we were all sharing stories of our journey and there are people who take their meds at night in order to sleep through the side effects. I can't remember now if these were Sprycel or Gleevec patients.

Perhaps you can get a sleeping aid from your doc and take it at the same time as Sprycel in the pm so you go to sleep before the headache strikes. Just an idea.

Susan L
----- Original Message ----- From: <[email protected]>
To: "CMLHope" <[email protected]>
Sent: Monday, March 22, 2010 6:56 PM
Subject: [CMLHope] More Questions About Sprycel


Hello everyone, Hope all is well. I hate to be such a nuisance, but I
have a question about the sprycel. The directions say to take in the
morning, but as I mentioned before, they give me an excruciating
headache and my chest feels...I really don't know how to describe it,
I guess you could say, I have a tight feeling in my chest. Does anyone
take their sprycel at night? I used to take my Gleevec at night
usually eat a small bowl of cereal or oatmeal  just so I could sleep
through the side effects and my onc/hemo said this was fine but I
don't know if the sprycel can be taken like this too. The headache is
so bad, it may interfere with my sleep.....I don't know. Please
someone advise me on this. Thanks
Love,peace,hope & prayers, Pat

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