its been a couple of years since I signed in and forgot my pass work andy idea of how I can get it back???? JUDY
________________________________ From: Rob <[email protected]> To: [email protected] Sent: Sat, September 18, 2010 10:34:54 PM Subject: Re: [CMLHope] Cure possible for CML? http://community.lls.org/thread/4670;jsessionid=762495A7D980475849018A307757F5F6 That is a really interesting story especially since Zileuton is already FDA approved and on the market. Rob On Sat, Sep 18, 2010 at 2:09 PM, Ricardo Gadelha <[email protected]> wrote: http://community.lls.org/thread/4670;jsessionid=762495A7D980475849018A307757F5F6 > >http://www.bangordailynews.com/detail/108012.html >http://ellsworthmaine.com/site/index.php/2008031313384/Lab-Report/Lab-Is-Home-to-Chinese-Scientists-Leukemia-Research.htmlhttp://www.bangordailynews.com/detail/108012.html > > >Jackson Lab work IDs gene; asthma drug foils cancer cellsCure possible for one >type of leukemia > >By Meg Haskell >BDN Staff 6/10/09 > > >A physician and researcher affiliated with The Jackson Laboratory in Bar >Harbor >says he may have identified a cure for the most common form of human leukemia. >Dr. Shaoguang Li, now conducting research at the University of Massachusetts >Medical School in Worcester, has identified a specific gene that supports the >development of chronic myeloid leukemia, as well as a drug treatment that >targets that gene to short-circuit the proliferation of leukemic blood cells. >In a telephone interview Tuesday, Li said the results of his study, published >in >the current issue of the journal Natural Genetics, is good news for victims of >chronic myeloid leukemia. >“The power of this strategy is for curing the disease, not just controlling >it,” >Li said. >The gene, called Alox5, allows leukemia-producing stem cells to develop and >proliferate, Li said. >In research at The Jackson Laboratory, Li studied mice that had been specially >bred to lack the Alox5 gene. >“If you remove the gene from a mouse, you don’t see leukemia develop,” he >said. >That’s because Alox5 is somehow tied to the development of cancer stem cells, >the precursors to leukemia, he said. >Li also studied normal mice with leukemia, targeting the Alox5 gene with the >drug Zileuton, which is approved for treating asthma. Zileuton successfully >blocked the gene’s production of an enzyme that turns cancer stem cells into >full-blown leukemia cells. >“When you block the gene’s function by using the drug … you’re going to be >leukemia-free,” Li said. >Mice treated with a combination of Zileuton and Gleevec, the most effective >treatment currently available for chronic myeloid leukemia, fared even better >than mice treated with either medication alone. >Li said Zileuton must now be studied in human clinical trials before it can be >prescribed for leukemia patients. >“A lot of patients will be interested” in participating in those trials, he >forecast. “This is for a cure.” >Already, he said, he has been contacted by the father of a young leukemia >patient about participating in a clinical trial. The drug’s current approval >for >use in treating asthma should fast-track the clinical studies, he said, but he >declined to speculate on a timeline. >Li said there are larger implications as well. >“Now we know we can target cancer stem cells without damaging other stem >cells,” >he said. “Without this gene, normal blood can be produced, but the leukemia >disappears.” >In a news release issued earlier this week, The Jackson Laboratory said it is >seeking “patent protection” on the treatment developed by Li and his research >colleagues at the University of Massachusetts Medical Center and the >Dana-Farber >Cancer Institute at the Harvard Medical School. >Li, who retains adjunct professor status at The Jackson Laboratory, said the >Bar >Harbor lab could “benefit a great deal” from his research findings. >-- >[CMLHope] >A support group of http://cmlhope.com >------------------------------------------------- > >You received this message because you are subscribed to the Google Groups >"CMLHope" group. >To post to this group, send email to [email protected] >To unsubscribe from this group, send email to >[email protected] >For more options, visit this group at http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope
