Thanks for this interesting article! It appears that in January of this year Mass Univ took it into Phase I of test trials. However, Phase I is patient safety, Phase II is effectiveness, Phase III is to determine if it is more effective than what is already available. Their run time for Phase I is two years...but they are indicated that with time to compile data it won't even be ready for Phase II until 2014. They are seeking a patent...but I am not clear on what, since the drug is already on the market...maybe their testing protocol??? I am curious if anyone knows of any docs who may have jumped the gun on approval for CML treatment and may be using it already, off label or for patients who also have asthma? It would seem like since the Phase I - III, FDA approval and actual public release are already completed on both Gleevec and Zileuton there would be a way to fast track this.
Peg On Sep 18, 9:24 pm, judy <[email protected]> wrote: > its been a couple of years since I signed in and forgot my pass work andy idea > of how I can get it back???? JUDY > > ________________________________ > From: Rob <[email protected]> > To: [email protected] > Sent: Sat, September 18, 2010 10:34:54 PM > Subject: Re: [CMLHope] Cure possible for > CML?http://community.lls.org/thread/4670;jsessionid=762495A7D980475849018... > > That is a really interesting story especially since Zileuton is already FDA > approved and on the market. > > Rob > > On Sat, Sep 18, 2010 at 2:09 PM, Ricardo Gadelha <[email protected]> > wrote: > > http://community.lls.org/thread/4670;jsessionid=762495A7D980475849018... > > > > > > >http://www.bangordailynews.com/detail/108012.html > >http://ellsworthmaine.com/site/index.php/2008031313384/Lab-Report/Lab... > > >Jackson Lab work IDs gene; asthma drug foils cancer cellsCure possible for > >one > >type of leukemia > > > >By Meg Haskell > >BDN Staff 6/10/09 > > >A physician and researcher affiliated with The Jackson Laboratory in Bar > >Harbor > >says he may have identified a cure for the most common form of human > >leukemia. > >Dr. Shaoguang Li, now conducting research at the University of Massachusetts > >Medical School in Worcester, has identified a specific gene that supports the > >development of chronic myeloid leukemia, as well as a drug treatment that > >targets that gene to short-circuit the proliferation of leukemic blood cells. > >In a telephone interview Tuesday, Li said the results of his study, > >published in > >the current issue of the journal Natural Genetics, is good news for victims > >of > >chronic myeloid leukemia. > >“The power of this strategy is for curing the disease, not just controlling > >it,” > >Li said. > >The gene, called Alox5, allows leukemia-producing stem cells to develop and > >proliferate, Li said. > >In research at The Jackson Laboratory, Li studied mice that had been > >specially > >bred to lack the Alox5 gene. > >“If you remove the gene from a mouse, you don’t see leukemia develop,” he > >said. > >That’s because Alox5 is somehow tied to the development of cancer stem cells, > >the precursors to leukemia, he said. > >Li also studied normal mice with leukemia, targeting the Alox5 gene with the > >drug Zileuton, which is approved for treating asthma. Zileuton successfully > >blocked the gene’s production of an enzyme that turns cancer stem cells into > >full-blown leukemia cells. > >“When you block the gene’s function by using the drug … you’re going to be > >leukemia-free,” Li said. > >Mice treated with a combination of Zileuton and Gleevec, the most effective > >treatment currently available for chronic myeloid leukemia, fared even better > >than mice treated with either medication alone. > >Li said Zileuton must now be studied in human clinical trials before it can > >be > >prescribed for leukemia patients. > >“A lot of patients will be interested” in participating in those trials, he > >forecast. “This is for a cure.” > >Already, he said, he has been contacted by the father of a young leukemia > >patient about participating in a clinical trial. The drug’s current approval > >for > >use in treating asthma should fast-track the clinical studies, he said, but > >he > >declined to speculate on a timeline. > >Li said there are larger implications as well. > >“Now we know we can target cancer stem cells without damaging other stem > >cells,” > >he said. “Without this gene, normal blood can be produced, but the leukemia > >disappears.” > >In a news release issued earlier this week, The Jackson Laboratory said it is > >seeking “patent protection” on the treatment developed by Li and his research > >colleagues at the University of Massachusetts Medical Center and the > >Dana-Farber > >Cancer Institute at the Harvard Medical School. > >Li, who retains adjunct professor status at The Jackson Laboratory, said the > >Bar > >Harbor lab could “benefit a great deal” from his research findings. > >-- > >[CMLHope] > >A support group ofhttp://cmlhope.com > >------------------------------------------------- > > > >You received this message because you are subscribed to the Google Groups > >"CMLHope" group. > >To post to this group, send email to [email protected] > >To unsubscribe from this group, send email to > >[email protected] > >For more options, visit this group athttp://groups.google.com/group/CMLHope > > -- > [CMLHope] > A support group ofhttp://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group athttp://groups.google.com/group/CMLHope- > Hide quoted text - > > - Show quoted text - -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. 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