Kelly, I started Gleevec in one of the first studies in Chicago Feb 5th 2000. I started at 400 mg but then I got the Gleevec Rash and they had no idea what was going on. They gave me creams to but on the rash but did little help. So they dropped me down to 300 mg which was the lowest that the Doctor in the study would let me take. I've been on that amount almost from the start. I talked to them about putting back up to 400 mg put they told if it's not broken don't try to fix it. My counts are just find. Hope this helps. Greenie
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