I am an example that you do not need to follow the standard treatment dosing of 400 mg. At 400 mg I had muscle cramping so bad that it woke me at night, prevented me from doing the crafts I love to do because my hands cramped with the slightest fine movement. It even caused me to stumble at times because my feet and legs cramped so badly. I went on Gleevec on Sept 4, 2004 and after dealing with the cramping for 3 months, my Oncologist dropped my dose to 300mg in Jan of 2005. I have been on 300mg a day since then, have had a complete molecular response with no detectable bcr-abl since then.
Just make sure your oncologist is following your blood work frequently. I have bloodwork drawn every 2 to 3 months, I have flow cytometry for bcr-able by FISH every 6 months and a bone marrow biopsy about every other year. I am in 100% molecular remission taking 300mg daily for the last 6 years. From: [email protected] [mailto:[email protected]] On Behalf Of [email protected] Sent: Saturday, June 11, 2011 6:38 AM To: Digest Recipients Subject: [CMLHope] Digest for [email protected] - 4 Messages in 2 Topics Today's Topic Summary Group: http://groups.google.com/group/cmlhope/topics * 200mg/day effective for normal male? <> [2 Updates] * dasatinib and hyperthyroidism <> [2 Updates] Topic: 200mg/day effective for normal male? <http://groups.google.com/group/cmlhope/t/5fc49ae905f0db3b> Dour Daze <[email protected]> Jun 10 01:26PM -0700 ^ <> What would you expect to transpire to a newly diagnosed cml patient chronic phase... male 6'0 if he is treated for a long period of time (more than 7 months) on 200 mg/day of Gleevec? What is the risk of the lower dosage? DD "Pat Elliot" <[email protected]> Jun 10 06:30PM -0700 ^ <> The risk is a lack of response and that could lead to multiple complications including going into blast crisis. This could put the patient's life at risk. The standard dosage is 400 mg/day. How is the patient being monitored and what have the tests shown? Has a reason been given for not following the standard protocol for CML treatment? Pat in Phoenix -----Original Message----- From: [email protected] [mailto:[email protected]] On Behalf Of Dour Daze Sent: Friday, June 10, 2011 1:26 PM To: CMLHope Subject: [CMLHope] 200mg/day effective for normal male? What would you expect to transpire to a newly diagnosed cml patient chronic phase... male 6'0 if he is treated for a long period of time (more than 7 months) on 200 mg/day of Gleevec? What is the risk of the lower dosage? DD -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope Topic: dasatinib and hyperthyroidism <http://groups.google.com/group/cmlhope/t/d50db76908b3185f> Martin Gartenberg <[email protected]> Jun 10 09:38AM -0400 ^ <> Hi, Actually I am not on any medication for CML because i had a bone marrow transplant more then 22 years ago but did develop hyperthyroidism because of all the radiation and chemotherapy I received. You really don't have to worry about it because there is a very simple solution to the problem. I use a drug called Levothyroxine which is a generic for Synthroid and is very inexpensive and really has no side effects except for making you feel much better. I use a very small dose .075 micrograms once a day. It is a little blue pill that takes your blues away. That's about it for your thyroid problem. I wish you continued health and happiness. And also *18's*. In the Hebrew language the number 18 represents life, which is pronounced as Chi. It is said as if you were clearing your throat. Marty Tracey <[email protected]> Jun 10 08:46AM -0700 ^ <> Hi Marty, I believe what you have is actually hypothyroidism. This is when your thyroid is under active. The drug Levothyroxine helps to compensate for that but in Mr Grinch's case, he said that has hyperthyroidism which is actually the opposite of what you have, it's an over active thyroid. If he took Levothyroxine, it would probably kill him. Unfortunately for Mr Grinch, hyperthyroidism is much more difficult to treat than hypothyroidism. Tracey --- On Fri, 6/10/11, Martin Gartenberg <[email protected]> wrote: From: Martin Gartenberg <[email protected]> Subject: Re: [CMLHope] dasatinib and hyperthyroidism To: [email protected] Date: Friday, June 10, 2011, 9:38 AM Hi, Actually I am not on any medication for CML because i had a bone marrow transplant more then 22 years ago but did develop hyperthyroidism because of all the radiation and chemotherapy I received. You really don't have to worry about it because there is a very simple solution to the problem. I use a drug called Levothyroxine which is a generic for Synthroid and is very inexpensive and really has no side effects except for making you feel much better. I use a very small dose .075 micrograms once a day. It is a little blue pill that takes your blues away. That's about it for your thyroid problem. I wish you continued health and happiness. And also 18's. In the Hebrew language the number 18 represents life, which is pronounced as Chi. It is said as if you were clearing your throat. Marty On Wed, Jun 8, 2011 at 6:16 PM, MrGrinch <[email protected]> wrote: I was diagnosed with CML in Nov 2010 and began treatment on dasatinib later that month. My numbers are all going the right direction, which is great, but was getting an increasing amount of side effects. Several of the side effects were not normal for that drug, so I went to an endocrinologist and have discovered that I now have a significant thyroid problem. Has anyone else experienced hyperthyroidism after taking this drug? -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope
