Has anyone on sprycel run into an acne problem? On Dec 9, 2011 10:49 AM, <[email protected]> wrote:
> ** > Greenie...thanks for your response. I didn't remain on Gleevec at 300mg > long because the rash worsened. Started to affect my fingernails, etc. > Dr's at MDA took one look and stopped it. If the Sprycel doesn't work at a > lower level I will suggest giving Gleevec another try. Have a great > holiday! Tom in KY > > In a message dated 12/8/2011 5:53:15 P.M. Eastern Standard Time, > [email protected] writes: > > Tom, (1) when you started Gleevec and you received the rash how long did > it last? (2) when they dropped you from 400 mg to 300mg did the rash start > to go away. I started Gleevec in Feb. of 2000 with 400 mg, I also got > the Gleevec rash and being in a study at Chicago they had no idea what to > think of it. They gave me a cream to apply to the areas put that did not > help. > > They then dropped me down to 300 mg and I've been on this amount all of > these years. The rash lasted for about 2 months then it started to slowly > go away and never returned. The rash covered the bottom of my feet, my > arms, the top of my hands and all over my chest. And their were little > bumps on the palms of hands and the bottom of my feet. I don't know if > this info will help but this is what happened to me. Their were only 8 > people in my study and I don't have any idea what happened to any of them. > I've asked but they won't tell me anything. Hope this can help. > > greenie > > In a message dated 12/8/2011 10:48:38 A.M. Eastern Standard Time, > [email protected] writes: > > I have just found out that I have Pleural Effusion and a little > Pericardial Effusion apparently from my Sprycel use. I have been on > Sprycel for about two years (100mg/day) and noticed some shortness of > breath and chest pain. Xrays confirmed that one lung sack was about 30% > full of fluid and an Echo Cardiogram confirmed the heart fluid buildup. I > have just had a CT exam to further define the problems. A summary of my CML > journey is given below. > > I am fortunate to have great Doctors...one at MD Anderson and one in KY > who are heavily involved. > > I have several questions for those that may have been down this same > road... > > 1. They put me on 50 mg of Prednisone and stopped my Sprycel > immediately...suggesting that they will restart it at a lower dose when the > fluid clears up. Did anyone out there have this same treatment? How do > the lower doses do in controlling the CML? Did anyone have problems with > Prednisone? I am generally adverse to taking lots of steroids. > 2. Sprycel is my 3rd try at a TKI for CML. I was unable to take Gleevec > and Tasigna successfully. If I can't tolerate Sprycel, are there any other > experimental drugs that you are aware of that are a possibility? I know > MDA has several studies going on in this reguard. > 3. Do any of you have Pericardial Effusion....and if so, what was done to > treat it? > > Thanks for any help you can provide. I look at this as just another speed > bump in the CML journey and feel fortunate that we have so many options > available for treatment. > > Tom in KY > > *Tom Dunham, BD: 8/1941* > ** > DX CML 12-23-2008 > MDA Protocol: Tasigna-400mg; 2xday-1/09 > On Flecainide for AF...still had frequent episodes > Q PCR bone@ 0.17 on 7/09 > Acute Pancreatitis-7/5/09 > Stopped Tasigna-7/13/09 > Q PCRU blood-7-29-09 ! > Started Gleevec-400mg/day-7/31/09 > Developed rash ~ 8/19/09 > Rash treated with Steroids..improvement > Rash worsens~9/22/09 > Stopped Gleevec-9/28/09 > Restarted Gleevec @300mg/day-10/8/09 > Stopped Gleevec-10/13/09-toxic rash\ > AF returned infrequently > Q PCR bone-0.05 > Started Sprycel @ 100mg/day-10/20/09 > Some AF...increased FLecainde..1, 2x/day > Q PCR bone..0.07 > Stopped Alcohol…no AF, ½ Flecainide 2x/day > Q PCR Blood…Non Detectible-12-13-10 > Q PCR Bone..0.01--2-25-11 > Q PCR Blood…Undetectible-5-19-11 > Reduced Flecainide to 1/2 per day > Pleural and pericardial Effusion: stopped Sprycel-12-6-'11 > Prednisone 50mg /day to combat PE > > > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at > http://groups.google.com/group/CMLHope > > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at > http://groups.google.com/group/CMLHope > > -- > [CMLHope] > A support group of http://cmlhope.com > ------------------------------------------------- > > You received this message because you are subscribed to the Google Groups > "CMLHope" group. > To post to this group, send email to [email protected] > To unsubscribe from this group, send email to > [email protected] > For more options, visit this group at > http://groups.google.com/group/CMLHope -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. 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