Angelyn: I was in complete molecular remission. I stopped Gleevec in December to commence another medication for my CLL. A PCR was done in March and I was positive for CML. I went back on Gleevec (concurrently administered with a reduced dose of my CLL med), and now, 3 months later, I have a major molecular response. --David from Michigan
To: [email protected] From: [email protected] Subject: [CMLHope] Digest for [email protected] - 3 updates in 1 topic Date: Wed, 17 Jun 2015 10:21:09 +0000 [email protected] Google Groups Topic digest View all topics Stopping Gleevec - 3 Updates Stopping Gleevec ANGELYN ESDERS <[email protected]>: Jun 17 01:02AM I just received an email from my oncologist telling me that it is safe for me to stop Gleevec for 3 months.I started Gleevec in January 2001, and reached cytogenic remission in July 2001. I've continued on 300mg per day.I was in the study for 12 years.I feel like it is my safety net between wellness and reoccurrence of CML.I am almost afraid to stop it. I no longer have any side effects from it.Who has stopped Gleevec, and what have you experienced as a result of doing so?Thanking you all for your input...Angie in Canada Giora Sharf <[email protected]>: Jun 17 09:35AM +0300 Hi Angie We have similar story. I started Glivec on 14.2.2001 and was on 400 mg till 10.6.2014 when I agreed to my Dr's advise to stop. I am now 1 year without treatment doing very well, monthly PCR are all in deep MR4.5 response. I fully understand your concern, I had the same issues and didn’t agree to stop for couple of years. When I saw the data indicating that all the patients who stop and relapse (about 50-60 %) respond well when they restart treatment, I agreed to stop. I also didn’t have severe side effects on Glivec, but I am happy to be drug free and do very strict monthly or 6 weeks monitoring. Please remember if you decide to stop- the most important thing is a very strict monthly PCR on international scale. (IS) Good luck whatever you decide Giora From: [email protected] [mailto:[email protected]] On Behalf Of ANGELYN ESDERS Sent: Wednesday, June 17, 2015 4:03 AM To: [email protected] Subject: [CMLHope] Stopping Gleevec I just received an email from my oncologist telling me that it is safe for me to stop Gleevec for 3 months. I started Gleevec in January 2001, and reached cytogenic remission in July 2001. I've continued on 300mg per day. I was in the study for 12 years. I feel like it is my safety net between wellness and reoccurrence of CML. I am almost afraid to stop it. I no longer have any side effects from it. Who has stopped Gleevec, and what have you experienced as a result of doing so? Thanking you all for your input... Angie in Canada -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout. ANGELYN ESDERS <[email protected]>: Jun 17 10:12AM Thank you for your kind letter, Giora. I remember you from years back. You live in Tel Aviv? I am so happy to hear that you are doing so well. I feel encouraged.Angie From: Giora Sharf <[email protected]> To: [email protected] Sent: Wednesday, June 17, 2015 2:35 AM Subject: RE: [CMLHope] Stopping Gleevec #yiv1061552755 #yiv1061552755 -- _filtered #yiv1061552755 {panose-1:2 4 5 3 5 4 6 3 2 4;} _filtered #yiv1061552755 {font-family:Calibri;panose-1:2 15 5 2 2 2 4 3 2 4;} _filtered #yiv1061552755 {font-family:Tahoma;panose-1:2 11 6 4 3 5 4 4 2 4;} _filtered #yiv1061552755 {font-family:Garamond;panose-1:2 2 4 4 3 3 1 1 8 3;}#yiv1061552755 #yiv1061552755 p.yiv1061552755MsoNormal, #yiv1061552755 li.yiv1061552755MsoNormal, #yiv1061552755 div.yiv1061552755MsoNormal {margin:0cm;margin-bottom:.0001pt;font-size:12.0pt;}#yiv1061552755 a:link, #yiv1061552755 span.yiv1061552755MsoHyperlink {color:blue;text-decoration:underline;}#yiv1061552755 a:visited, #yiv1061552755 span.yiv1061552755MsoHyperlinkFollowed {color:purple;text-decoration:underline;}#yiv1061552755 p {margin-right:0cm;margin-left:0cm;font-size:12.0pt;}#yiv1061552755 span.yiv1061552755EmailStyle18 {color:#1F497D;}#yiv1061552755 .yiv1061552755MsoChpDefault {font-size:10.0pt;} _filtered #yiv1061552755 {margin:72.0pt 90.0pt 72.0pt 90.0pt;}#yiv1061552755 div.yiv1061552755WordSection1 {}#yiv1061552755 Hi AngieWe have similar story. I started Glivec on 14.2.2001 and was on 400 mg till 10.6.2014 when I agreed to my Dr's advise to stop. I am now 1 year without treatment doing very well, monthly PCR are all in deep MR4.5 response.I fully understand your concern, I had the same issues and didn’t agree to stop for couple of years. When I saw the data indicating that all the patients who stop and relapse (about 50-60 %) respond well when they restart treatment, I agreed to stop. I also didn’t have severe side effects on Glivec, but I am happy to be drug free and do very strict monthly or 6 weeks monitoring. Please remember if you decide to stop- the most important thing is a very strict monthly PCR on international scale. (IS)Good luck whatever you decideGiora From: [email protected] [mailto:[email protected]] On Behalf Of ANGELYN ESDERS Sent: Wednesday, June 17, 2015 4:03 AM To: [email protected] Subject: [CMLHope] Stopping Gleevec I just received an email from my oncologist telling me that it is safe for me to stop Gleevec for 3 months.I started Gleevec in January 2001, and reached cytogenic remission in July 2001. I've continued on 300mg per day.I was in the study for 12 years.I feel like it is my safety net between wellness and reoccurrence of CML.I am almost afraid to stop it. I no longer have any side effects from it.Who has stopped Gleevec, and what have you experienced as a result of doing so?Thanking you all for your input...Angie in Canada-- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout.-- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. For more options, visit https://groups.google.com/d/optout. Back to top You received this digest because you're subscribed to updates for this group. You can change your settings on the group membership page. To unsubscribe from this group and stop receiving emails from it send an email to [email protected]. -- -- [CMLHope] A support group of http://cmlhope.com ------------------------------------------------- You received this message because you are subscribed to the Google Groups "CMLHope" group. To post to this group, send email to [email protected] To unsubscribe from this group, send email to [email protected] For more options, visit this group at http://groups.google.com/group/CMLHope --- You received this message because you are subscribed to the Google Groups "CMLHope" group. To unsubscribe from this group and stop receiving emails from it, send an email to [email protected]. 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